Pediatric dose selection

D. R. Abernethy, G. J. Burckart

Research output: Contribution to journalArticle

Abstract

Selection of a drug dose in pediatrics is generally based on no or incomplete pharmacokinetic data. Traditionally, allometric, or scaling, techniques have been used; however, they have inherent limitations and may not make optimal use of the drug-specific clinical pharmacokinetic information that is available. Modeling is a tool that holds promise. The future challenge is to create a structured approach to determining pediatric doses for new therapeutic agents.

Original languageEnglish (US)
Pages (from-to)270-271
Number of pages2
JournalClinical Pharmacology and Therapeutics
Volume87
Issue number3
DOIs
StatePublished - Mar 2010
Externally publishedYes

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Pharmacokinetics
Pediatrics
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Pediatric dose selection. / Abernethy, D. R.; Burckart, G. J.

In: Clinical Pharmacology and Therapeutics, Vol. 87, No. 3, 03.2010, p. 270-271.

Research output: Contribution to journalArticle

Abernethy, DR & Burckart, GJ 2010, 'Pediatric dose selection', Clinical Pharmacology and Therapeutics, vol. 87, no. 3, pp. 270-271. https://doi.org/10.1038/clpt.2009.292
Abernethy, D. R. ; Burckart, G. J. / Pediatric dose selection. In: Clinical Pharmacology and Therapeutics. 2010 ; Vol. 87, No. 3. pp. 270-271.
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