Pediatric dose selection

D. R. Abernethy; G. J. Burckart

doi:10.1038/clpt.2009.292

Pediatric dose selection

D. R. Abernethy, G. J. Burckart

Research output: Contribution to journal › Comment/debate › peer-review

25 Scopus citations

Abstract

Selection of a drug dose in pediatrics is generally based on no or incomplete pharmacokinetic data. Traditionally, allometric, or scaling, techniques have been used; however, they have inherent limitations and may not make optimal use of the drug-specific clinical pharmacokinetic information that is available. Modeling is a tool that holds promise. The future challenge is to create a structured approach to determining pediatric doses for new therapeutic agents.

Original language	English (US)
Pages (from-to)	270-271
Number of pages	2
Journal	Clinical pharmacology and therapeutics
Volume	87
Issue number	3
DOIs	https://doi.org/10.1038/clpt.2009.292
State	Published - Mar 2010
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1038/clpt.2009.292

Cite this

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author = "Abernethy, {D. R.} and Burckart, {G. J.}",

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AU - Burckart, G. J.

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AB - Selection of a drug dose in pediatrics is generally based on no or incomplete pharmacokinetic data. Traditionally, allometric, or scaling, techniques have been used; however, they have inherent limitations and may not make optimal use of the drug-specific clinical pharmacokinetic information that is available. Modeling is a tool that holds promise. The future challenge is to create a structured approach to determining pediatric doses for new therapeutic agents.

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Pediatric dose selection

Abstract

ASJC Scopus subject areas

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