Case narrative Osteosarcoma is a highly malignant bone cancer with a predilection for spreading to the lungs that primarily affects adolescents. Non-metastatic osteosarcoma has an approximate cure rate of 70%. Patients with osteosarcoma and metastases at the time of diagnosis are cured less than 20% of the time. Treatment consists of surgery and chemotherapy. Many children with cancer are treated according to clinical research trials. Michael, a 15-year-old with metastatic osteosarcoma, has not responded to conventional therapy. For almost one year, he was treated on a therapeutic randomized clinical trial, which consisted of standard therapy (up-front chemotherapy, limb salvage surgery, and postsurgical chemotherapy). When his cancer responded poorly to up-front therapy he was randomized to receive additional “experimental” chemotherapy.
|Original language||English (US)|
|Title of host publication||Clinical Ethics in Pediatrics|
|Subtitle of host publication||A Case-Based Textbook|
|Publisher||Cambridge University Press|
|Number of pages||6|
|State||Published - Jan 1 2011|
ASJC Scopus subject areas