Pediatric brain tumors: Current knowledge and therapeutic opportunities

John Glod, Gilbert J. Rahme, Harpreet Kaur, Eric Raabe, Eugene I. Hwang, Mark A. Israel

Research output: Contribution to journalReview article

Abstract

Great progress has been made in many areas of pediatric oncology. However, tumours of the central nervous system (CNS) remain a significant challenge. A recent explosion of data has led to an opportunity to understand better the molecular basis of these diseases and is already providing a foundation for the pursuit of rationally chosen therapeutics targeting relevant molecular pathways. The molecular biology of pediatric brain tumours is shifting from a singular focus on basic scientific discovery to a platform upon which insights are being translated into therapies.

Original languageEnglish (US)
Pages (from-to)249-260
Number of pages12
JournalJournal of Pediatric Hematology/Oncology
Volume38
Issue number4
DOIs
StatePublished - 2016
Externally publishedYes

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Brain Neoplasms
Pediatrics
Central Nervous System Neoplasms
Explosions
Molecular Biology
Therapeutics

Keywords

  • Diffuse intrinsic pontine glioma
  • Ependymoma
  • Medulloblastoma
  • Pediatric glioma
  • Sega

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

Pediatric brain tumors : Current knowledge and therapeutic opportunities. / Glod, John; Rahme, Gilbert J.; Kaur, Harpreet; Raabe, Eric; Hwang, Eugene I.; Israel, Mark A.

In: Journal of Pediatric Hematology/Oncology, Vol. 38, No. 4, 2016, p. 249-260.

Research output: Contribution to journalReview article

Glod, John ; Rahme, Gilbert J. ; Kaur, Harpreet ; Raabe, Eric ; Hwang, Eugene I. ; Israel, Mark A. / Pediatric brain tumors : Current knowledge and therapeutic opportunities. In: Journal of Pediatric Hematology/Oncology. 2016 ; Vol. 38, No. 4. pp. 249-260.
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