Pediatric brain tumors: Current knowledge and therapeutic opportunities

John Glod, Gilbert J. Rahme, Harpreet Kaur, Eric Raabe, Eugene I. Hwang, Mark A. Israel

Research output: Contribution to journalReview article

Abstract

Great progress has been made in many areas of pediatric oncology. However, tumours of the central nervous system (CNS) remain a significant challenge. A recent explosion of data has led to an opportunity to understand better the molecular basis of these diseases and is already providing a foundation for the pursuit of rationally chosen therapeutics targeting relevant molecular pathways. The molecular biology of pediatric brain tumours is shifting from a singular focus on basic scientific discovery to a platform upon which insights are being translated into therapies.

Original languageEnglish (US)
Pages (from-to)249-260
Number of pages12
JournalJournal of Pediatric Hematology/Oncology
Volume38
Issue number4
DOIs
Publication statusPublished - 2016
Externally publishedYes

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Keywords

  • Diffuse intrinsic pontine glioma
  • Ependymoma
  • Medulloblastoma
  • Pediatric glioma
  • Sega

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

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