Pediatric brain tumors: Current knowledge and therapeutic opportunities

John Glod; Gilbert J. Rahme; Harpreet Kaur; Eric H. Raabe; Eugene I. Hwang; Mark A. Israel

doi:10.1097/MPH.0000000000000551

Pediatric brain tumors: Current knowledge and therapeutic opportunities

John Glod, Gilbert J. Rahme, Harpreet Kaur, Eric H. Raabe, Eugene I. Hwang, Mark A. Israel

School of Medicine

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Great progress has been made in many areas of pediatric oncology. However, tumours of the central nervous system (CNS) remain a significant challenge. A recent explosion of data has led to an opportunity to understand better the molecular basis of these diseases and is already providing a foundation for the pursuit of rationally chosen therapeutics targeting relevant molecular pathways. The molecular biology of pediatric brain tumours is shifting from a singular focus on basic scientific discovery to a platform upon which insights are being translated into therapies.

Original language	English (US)
Pages (from-to)	249-260
Number of pages	12
Journal	Journal of Pediatric Hematology/Oncology
Volume	38
Issue number	4
DOIs	https://doi.org/10.1097/MPH.0000000000000551
State	Published - 2016

Keywords

Diffuse intrinsic pontine glioma
Ependymoma
Medulloblastoma
Pediatric glioma
Sega

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1097/MPH.0000000000000551

Cite this

@article{dea21cd43d7f43fb826df1ca0fc2163e,

title = "Pediatric brain tumors: Current knowledge and therapeutic opportunities",

abstract = "Great progress has been made in many areas of pediatric oncology. However, tumours of the central nervous system (CNS) remain a significant challenge. A recent explosion of data has led to an opportunity to understand better the molecular basis of these diseases and is already providing a foundation for the pursuit of rationally chosen therapeutics targeting relevant molecular pathways. The molecular biology of pediatric brain tumours is shifting from a singular focus on basic scientific discovery to a platform upon which insights are being translated into therapies.",

keywords = "Diffuse intrinsic pontine glioma, Ependymoma, Medulloblastoma, Pediatric glioma, Sega",

author = "John Glod and Rahme, {Gilbert J.} and Harpreet Kaur and Raabe, {Eric H.} and Hwang, {Eugene I.} and Israel, {Mark A.}",

year = "2016",

doi = "10.1097/MPH.0000000000000551",

language = "English (US)",

volume = "38",

pages = "249--260",

journal = "Journal of Pediatric Hematology/Oncology",

issn = "1077-4114",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

TY - JOUR

T1 - Pediatric brain tumors

T2 - Current knowledge and therapeutic opportunities

AU - Glod, John

AU - Rahme, Gilbert J.

AU - Kaur, Harpreet

AU - Raabe, Eric H.

AU - Hwang, Eugene I.

AU - Israel, Mark A.

PY - 2016

Y1 - 2016

N2 - Great progress has been made in many areas of pediatric oncology. However, tumours of the central nervous system (CNS) remain a significant challenge. A recent explosion of data has led to an opportunity to understand better the molecular basis of these diseases and is already providing a foundation for the pursuit of rationally chosen therapeutics targeting relevant molecular pathways. The molecular biology of pediatric brain tumours is shifting from a singular focus on basic scientific discovery to a platform upon which insights are being translated into therapies.

AB - Great progress has been made in many areas of pediatric oncology. However, tumours of the central nervous system (CNS) remain a significant challenge. A recent explosion of data has led to an opportunity to understand better the molecular basis of these diseases and is already providing a foundation for the pursuit of rationally chosen therapeutics targeting relevant molecular pathways. The molecular biology of pediatric brain tumours is shifting from a singular focus on basic scientific discovery to a platform upon which insights are being translated into therapies.

KW - Diffuse intrinsic pontine glioma

KW - Ependymoma

KW - Medulloblastoma

KW - Pediatric glioma

KW - Sega

UR - http://www.scopus.com/inward/record.url?scp=84961226498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961226498&partnerID=8YFLogxK

U2 - 10.1097/MPH.0000000000000551

DO - 10.1097/MPH.0000000000000551

M3 - Review article

C2 - 26989915

AN - SCOPUS:84961226498

SN - 1077-4114

VL - 38

SP - 249

EP - 260

JO - Journal of Pediatric Hematology/Oncology

JF - Journal of Pediatric Hematology/Oncology

IS - 4

ER -

Pediatric brain tumors: Current knowledge and therapeutic opportunities

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this