Pediatric antimicrobial susceptibility trends across the United States

Pranita Tamma, Gwen L. Robinson, Jeffrey S. Gerber, Jason G. Newland, Chloe M. Delisle, Theoklis E. Zaoutis, Aaron Milstone

Research output: Contribution to journalArticle

Abstract

OBJECTIVE. Antimicrobial susceptibility patterns across US pediatric healthcare institutions are unknown. A national pooled pediatric antibiogram (1) identifies nationwide trends in antimicrobial resistance, (2) allows across-hospital benchmarking, and (3) provides guidance for empirical antimicrobial regimens for institutions unable to generate pediatric antibiograms. METHODS. In January 2012, a request for submission of pediatric antibiograms between 2005 and 2011 was sent to 233 US hospitals. A summary antibiogram was compiled from participating institutions to generate proportions of antimicrobial susceptibility. Temporal and regional comparisons were evaluated using χ2 tests and logistic regression, respectively. results. Of 200 institutions (85%) responding to our survey, 78 (39%) reported generating pediatric antibiograms, and 55 (71%) submitted antibiograms. Carbapenems had the highest activity against the majority of gram-negative organisms tested, but no antibiotic had more than 90% activity against Pseudomonas aeruginosa. Approximately 50% of all Staphylococcus aureus isolates were methicillin resistant. Western hospitals had significantly lower proportions of S. aureus that were methicillin resistant compared with all other regions tested. Overall, 21% of S. aureus isolates had resistance to clindamycin. Among Enterococcus faecium isolates, the prevalence of susceptibility to ampicillin (25%) and vancomycin (45%) was low but improved over time (P

Original languageEnglish (US)
Pages (from-to)1244-1251
Number of pages8
JournalInfection Control and Hospital Epidemiology
Volume34
Issue number12
DOIs
StatePublished - Dec 2013

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Microbial Sensitivity Tests
Pediatrics
Staphylococcus aureus
Benchmarking
Enterococcus faecium
Methicillin Resistance
Carbapenems
Clindamycin
Vancomycin
Ampicillin
Methicillin-Resistant Staphylococcus aureus
Pseudomonas aeruginosa
Logistic Models
Anti-Bacterial Agents
Delivery of Health Care

ASJC Scopus subject areas

  • Microbiology (medical)
  • Epidemiology
  • Infectious Diseases

Cite this

Tamma, P., Robinson, G. L., Gerber, J. S., Newland, J. G., Delisle, C. M., Zaoutis, T. E., & Milstone, A. (2013). Pediatric antimicrobial susceptibility trends across the United States. Infection Control and Hospital Epidemiology, 34(12), 1244-1251. https://doi.org/10.1086/673974

Pediatric antimicrobial susceptibility trends across the United States. / Tamma, Pranita; Robinson, Gwen L.; Gerber, Jeffrey S.; Newland, Jason G.; Delisle, Chloe M.; Zaoutis, Theoklis E.; Milstone, Aaron.

In: Infection Control and Hospital Epidemiology, Vol. 34, No. 12, 12.2013, p. 1244-1251.

Research output: Contribution to journalArticle

Tamma, P, Robinson, GL, Gerber, JS, Newland, JG, Delisle, CM, Zaoutis, TE & Milstone, A 2013, 'Pediatric antimicrobial susceptibility trends across the United States', Infection Control and Hospital Epidemiology, vol. 34, no. 12, pp. 1244-1251. https://doi.org/10.1086/673974
Tamma, Pranita ; Robinson, Gwen L. ; Gerber, Jeffrey S. ; Newland, Jason G. ; Delisle, Chloe M. ; Zaoutis, Theoklis E. ; Milstone, Aaron. / Pediatric antimicrobial susceptibility trends across the United States. In: Infection Control and Hospital Epidemiology. 2013 ; Vol. 34, No. 12. pp. 1244-1251.
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