Peak intraocular pressure and glaucomatous progression in primary open-angle glaucoma

Anastasios G.P. Konstas, Luciano Quaranta, Dimitrios G. Mikropoulos, Mayssa B. Nasr, Andrea Russo, Harris A. Jaffee, Jeanette A. Stewart, William C. Stewart

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Purpose: To evaluate the effect of 24-h peak intraocular pressure (IOP) on the progression of primary open-angle glaucoma (POAG) and the 24h time points that best predict peak pressure. Methods: A retrospective analysis of clinical data evaluating long-term glaucomatous progression in patients with POAG who were previously in a 24-h study of the authors (IOP readings at 2/6/10 A.M. and 2/6/10 PM); had ≥3 treated 10 A.M. (±1h) IOP measurements over 5-years after an untreated 24-h baseline; and had a treated 24-h curve with a 10 A.M. IOP±2mmHg within the 10 A.M. mean IOP over 5-years. Results: We included 98 nonprogressed and 53 progressed patients with POAG (n=151). The mean 24-h peak IOP (mmHg) was 19.9±2.7 for progressed and 18.3±2.0 for nonprogressed patients (P<0.001). Progressed patients also showed a higher mean 24-h IOP. Generally, patients with a mean or peak daytime (readings at 10 A.M., 2 and 6 P.M.) or 24-h peak IOP of ≤18 remained nonprogressed in 75%-78% of cases. Further, measuring IOP at night found a higher peak in only 20% of cases, which was ≤2 of the daytime peak in 98% of cases. A multivariate regression analysis showed only 24-h peak IOP as an independent risk factor for progression (P=0.002). Conclusions: This study suggests that daytime peak IOP may be clinically important in predicting long-term glaucomatous progression. Further, daytime peak IOP may assist, as much as daytime mean IOP and, in most cases, 24-h peak IOP, in helping to guide long-term treatment in POAG.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
JournalJournal of Ocular Pharmacology and Therapeutics
Issue number1
StatePublished - Feb 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Pharmacology
  • Pharmacology (medical)


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