PDZ domains in synapse assembly and signalling

Craig C. Garner, Joanne Nash, Richard L. Huganir

Research output: Contribution to journalReview articlepeer-review


Synaptic junctions are highly specialized structures designed to promote the rapid and efficient transmission of signals from the presynaptic terminal to the postsynaptic membrane within the central nervous system. Proteins containing PDZ domains play a fundamental organizational role at both the pre- and postsynaptic plasma membranes. This review focuses on recent advances in our understanding of the mechanisms underlying the assembly of synapses in the central nervous system. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)274-280
Number of pages7
JournalTrends in Cell Biology
Issue number7
StatePublished - Jul 1 2000

ASJC Scopus subject areas

  • Cell Biology


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