PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival

Steven Song, Andrew J. Ewald, William Stallcup, Zena Werb, Gabriele Bergers

Research output: Contribution to journalArticlepeer-review

Abstract

The microvasculature consists of endothelial cells and their surrounding pericytes. Few studies on the regulatory mechanisms of tumour angiogenesis have focused on pericytes. Here we report the identification of tumour-derived PDGFRβ+ (platelet-derived growth factor receptor β) progenitor perivascular cells (PPCs) that have the ability to differentiate into pericytes and regulate vessel stability and vascular survival in tumours. A subset of PDGFRβ+ PPCs is recruited from bone marrow to perivascular sites in tumours. Specific inhibition of PDGFRβ signalling eliminates PDGFRβ+ PPCs and mature pericytes around tumour vessels, leading to vascular hyperdilation and endothelial cell apoptosis in pancreatic islet tumours of transgenic Rip1Tag2 mice.

Original languageEnglish (US)
Pages (from-to)870-879
Number of pages10
JournalNature cell biology
Volume7
Issue number9
DOIs
StatePublished - Sep 2005
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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