PDGFRα-Positive B Cells Are Neural Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response to Increased PDGF Signaling

Erica L. Jackson, Jose Manuel Garcia-Verdugo, Sara Gil-Perotin, Monica Roy, Alfredo Quinones-Hinojosa, Scott VandenBerg, Arturo Alvarez-Buylla

Research output: Contribution to journalArticle

Abstract

Neurons and oligodendrocytes are produced in the adult brain subventricular zone (SVZ) from neural stem cells (B cells), which express GFAP and have morphological properties of astrocytes. We report here on the identification B cells expressing the PDGFRα in the adult SVZ. Specifically labeled PDGFRα expressing B cells in vivo generate neurons and oligodendrocytes. Conditional ablation of PDGFRα in a subpopulation of postnatal stem cells showed that this receptor is required for oligodendrogenesis, but not neurogenesis. Infusion of PDGF alone was sufficient to arrest neuroblast production and induce SVZ B cell proliferation contributing to the generation of large hyperplasias with some features of gliomas. The work demonstrates that PDGFRα signaling occurs early in the adult stem cell lineage and may help regulate the balance between oligodendrocyte and neuron production. Excessive PDGF activation in the SVZ in stem cells is sufficient to induce hallmarks associated with early stages of tumor formation.

Original languageEnglish (US)
Pages (from-to)187-199
Number of pages13
JournalNeuron
Volume51
Issue number2
DOIs
StatePublished - Jul 20 2006
Externally publishedYes

Fingerprint

Neural Stem Cells
Lateral Ventricles
Glioma
Oligodendroglia
B-Lymphocytes
Growth
Neurons
Stem Cells
Adult Stem Cells
Neurogenesis
Cell Lineage
Astrocytes
Hyperplasia
Cell Proliferation
Brain
Neoplasms

Keywords

  • DEVBIO
  • MOLNEURO
  • STEMCELL

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Jackson, E. L., Garcia-Verdugo, J. M., Gil-Perotin, S., Roy, M., Quinones-Hinojosa, A., VandenBerg, S., & Alvarez-Buylla, A. (2006). PDGFRα-Positive B Cells Are Neural Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response to Increased PDGF Signaling. Neuron, 51(2), 187-199. https://doi.org/10.1016/j.neuron.2006.06.012

PDGFRα-Positive B Cells Are Neural Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response to Increased PDGF Signaling. / Jackson, Erica L.; Garcia-Verdugo, Jose Manuel; Gil-Perotin, Sara; Roy, Monica; Quinones-Hinojosa, Alfredo; VandenBerg, Scott; Alvarez-Buylla, Arturo.

In: Neuron, Vol. 51, No. 2, 20.07.2006, p. 187-199.

Research output: Contribution to journalArticle

Jackson, EL, Garcia-Verdugo, JM, Gil-Perotin, S, Roy, M, Quinones-Hinojosa, A, VandenBerg, S & Alvarez-Buylla, A 2006, 'PDGFRα-Positive B Cells Are Neural Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response to Increased PDGF Signaling', Neuron, vol. 51, no. 2, pp. 187-199. https://doi.org/10.1016/j.neuron.2006.06.012
Jackson EL, Garcia-Verdugo JM, Gil-Perotin S, Roy M, Quinones-Hinojosa A, VandenBerg S et al. PDGFRα-Positive B Cells Are Neural Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response to Increased PDGF Signaling. Neuron. 2006 Jul 20;51(2):187-199. https://doi.org/10.1016/j.neuron.2006.06.012
Jackson, Erica L. ; Garcia-Verdugo, Jose Manuel ; Gil-Perotin, Sara ; Roy, Monica ; Quinones-Hinojosa, Alfredo ; VandenBerg, Scott ; Alvarez-Buylla, Arturo. / PDGFRα-Positive B Cells Are Neural Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response to Increased PDGF Signaling. In: Neuron. 2006 ; Vol. 51, No. 2. pp. 187-199.
@article{3950d3efb2a44eca922ca89a598d0e73,
title = "PDGFRα-Positive B Cells Are Neural Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response to Increased PDGF Signaling",
abstract = "Neurons and oligodendrocytes are produced in the adult brain subventricular zone (SVZ) from neural stem cells (B cells), which express GFAP and have morphological properties of astrocytes. We report here on the identification B cells expressing the PDGFRα in the adult SVZ. Specifically labeled PDGFRα expressing B cells in vivo generate neurons and oligodendrocytes. Conditional ablation of PDGFRα in a subpopulation of postnatal stem cells showed that this receptor is required for oligodendrogenesis, but not neurogenesis. Infusion of PDGF alone was sufficient to arrest neuroblast production and induce SVZ B cell proliferation contributing to the generation of large hyperplasias with some features of gliomas. The work demonstrates that PDGFRα signaling occurs early in the adult stem cell lineage and may help regulate the balance between oligodendrocyte and neuron production. Excessive PDGF activation in the SVZ in stem cells is sufficient to induce hallmarks associated with early stages of tumor formation.",
keywords = "DEVBIO, MOLNEURO, STEMCELL",
author = "Jackson, {Erica L.} and Garcia-Verdugo, {Jose Manuel} and Sara Gil-Perotin and Monica Roy and Alfredo Quinones-Hinojosa and Scott VandenBerg and Arturo Alvarez-Buylla",
year = "2006",
month = "7",
day = "20",
doi = "10.1016/j.neuron.2006.06.012",
language = "English (US)",
volume = "51",
pages = "187--199",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",

}

TY - JOUR

T1 - PDGFRα-Positive B Cells Are Neural Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response to Increased PDGF Signaling

AU - Jackson, Erica L.

AU - Garcia-Verdugo, Jose Manuel

AU - Gil-Perotin, Sara

AU - Roy, Monica

AU - Quinones-Hinojosa, Alfredo

AU - VandenBerg, Scott

AU - Alvarez-Buylla, Arturo

PY - 2006/7/20

Y1 - 2006/7/20

N2 - Neurons and oligodendrocytes are produced in the adult brain subventricular zone (SVZ) from neural stem cells (B cells), which express GFAP and have morphological properties of astrocytes. We report here on the identification B cells expressing the PDGFRα in the adult SVZ. Specifically labeled PDGFRα expressing B cells in vivo generate neurons and oligodendrocytes. Conditional ablation of PDGFRα in a subpopulation of postnatal stem cells showed that this receptor is required for oligodendrogenesis, but not neurogenesis. Infusion of PDGF alone was sufficient to arrest neuroblast production and induce SVZ B cell proliferation contributing to the generation of large hyperplasias with some features of gliomas. The work demonstrates that PDGFRα signaling occurs early in the adult stem cell lineage and may help regulate the balance between oligodendrocyte and neuron production. Excessive PDGF activation in the SVZ in stem cells is sufficient to induce hallmarks associated with early stages of tumor formation.

AB - Neurons and oligodendrocytes are produced in the adult brain subventricular zone (SVZ) from neural stem cells (B cells), which express GFAP and have morphological properties of astrocytes. We report here on the identification B cells expressing the PDGFRα in the adult SVZ. Specifically labeled PDGFRα expressing B cells in vivo generate neurons and oligodendrocytes. Conditional ablation of PDGFRα in a subpopulation of postnatal stem cells showed that this receptor is required for oligodendrogenesis, but not neurogenesis. Infusion of PDGF alone was sufficient to arrest neuroblast production and induce SVZ B cell proliferation contributing to the generation of large hyperplasias with some features of gliomas. The work demonstrates that PDGFRα signaling occurs early in the adult stem cell lineage and may help regulate the balance between oligodendrocyte and neuron production. Excessive PDGF activation in the SVZ in stem cells is sufficient to induce hallmarks associated with early stages of tumor formation.

KW - DEVBIO

KW - MOLNEURO

KW - STEMCELL

UR - http://www.scopus.com/inward/record.url?scp=33745880884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745880884&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2006.06.012

DO - 10.1016/j.neuron.2006.06.012

M3 - Article

VL - 51

SP - 187

EP - 199

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 2

ER -