PDGF receptor-to-nucleus signaling of p91 (STAT1α) transcription factor in rat smooth muscle cells

Hitomi Yamamoto, Michael Crow, Linda Cheng, Edward Lakatta, James Kinsella

Research output: Contribution to journalArticle

Abstract

Vascular smooth muscle cells (VSMC) are the predominant cell type in the media of a normal artery. Injury to the vessel wall leads to platelet deposition and the release of numerous factors, including PDGF, which exerts its biological effects by binding to specific surface receptors on the smooth muscle cell membrane. We demonstrate that PDGF-stimulated smooth muscle cells activate the STAT (signal transducers and activators of transcription) family of proteins in addition to other signaling pathways (e.g., RAS-RAF-MAP Kinase). We show that the transcription factor p91 (STAT1α) is rapidly activated by PDGF in VSMC and specifically binds to the regulatory elements SIR or GAS. We hypothesize that signal transduction by p91 plays an important role in VSMC, especially after injury with the release of growth factors such as PDGF.

Original languageEnglish (US)
Pages (from-to)125-130
Number of pages6
JournalExperimental Cell Research
Volume222
Issue number1
DOIs
StatePublished - Jan 10 1996
Externally publishedYes

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Platelet-Derived Growth Factor Receptors
Smooth Muscle Myocytes
Transcription Factors
Vascular Smooth Muscle
STAT Transcription Factors
Wounds and Injuries
Signal Transduction
Intercellular Signaling Peptides and Proteins
Phosphotransferases
Blood Platelets
Arteries
Cell Membrane
gamma interferon activation factor

ASJC Scopus subject areas

  • Cell Biology

Cite this

PDGF receptor-to-nucleus signaling of p91 (STAT1α) transcription factor in rat smooth muscle cells. / Yamamoto, Hitomi; Crow, Michael; Cheng, Linda; Lakatta, Edward; Kinsella, James.

In: Experimental Cell Research, Vol. 222, No. 1, 10.01.1996, p. 125-130.

Research output: Contribution to journalArticle

Yamamoto, Hitomi ; Crow, Michael ; Cheng, Linda ; Lakatta, Edward ; Kinsella, James. / PDGF receptor-to-nucleus signaling of p91 (STAT1α) transcription factor in rat smooth muscle cells. In: Experimental Cell Research. 1996 ; Vol. 222, No. 1. pp. 125-130.
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