TY - JOUR
T1 - PDGF receptor-to-nucleus signaling of p91 (STAT1α) transcription factor in rat smooth muscle cells
AU - Yamamoto, Hitomi
AU - Crow, Michael
AU - Cheng, Linda
AU - Lakatta, Edward
AU - Kinsella, James
PY - 1996/1/10
Y1 - 1996/1/10
N2 - Vascular smooth muscle cells (VSMC) are the predominant cell type in the media of a normal artery. Injury to the vessel wall leads to platelet deposition and the release of numerous factors, including PDGF, which exerts its biological effects by binding to specific surface receptors on the smooth muscle cell membrane. We demonstrate that PDGF-stimulated smooth muscle cells activate the STAT (signal transducers and activators of transcription) family of proteins in addition to other signaling pathways (e.g., RAS-RAF-MAP Kinase). We show that the transcription factor p91 (STAT1α) is rapidly activated by PDGF in VSMC and specifically binds to the regulatory elements SIR or GAS. We hypothesize that signal transduction by p91 plays an important role in VSMC, especially after injury with the release of growth factors such as PDGF.
AB - Vascular smooth muscle cells (VSMC) are the predominant cell type in the media of a normal artery. Injury to the vessel wall leads to platelet deposition and the release of numerous factors, including PDGF, which exerts its biological effects by binding to specific surface receptors on the smooth muscle cell membrane. We demonstrate that PDGF-stimulated smooth muscle cells activate the STAT (signal transducers and activators of transcription) family of proteins in addition to other signaling pathways (e.g., RAS-RAF-MAP Kinase). We show that the transcription factor p91 (STAT1α) is rapidly activated by PDGF in VSMC and specifically binds to the regulatory elements SIR or GAS. We hypothesize that signal transduction by p91 plays an important role in VSMC, especially after injury with the release of growth factors such as PDGF.
UR - http://www.scopus.com/inward/record.url?scp=0030042198&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030042198&partnerID=8YFLogxK
U2 - 10.1006/excr.1996.0016
DO - 10.1006/excr.1996.0016
M3 - Article
C2 - 8549654
AN - SCOPUS:0030042198
SN - 0014-4827
VL - 222
SP - 125
EP - 130
JO - Experimental cell research
JF - Experimental cell research
IS - 1
ER -