PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways

Jifeng Zhang, Mingui Fu, David Myles, Xiaojun Zhu, Jie Du, Xu Cao, Yuqing E. Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Osteoprotegerin (OPG) is a key regulator of osteoclastogenesis. Recent reports suggest that OPG may function as a protector of arterial calcification and survival of endothelial cells. However, the role and expression of OPG in vascular wall is unclear. Here we report that OPG was highly expressed in vascular smooth muscle cells (VSMC) but not in endothelial cells. Platelet-derived growth factor (PDGF), basic fibroblast growth factor, angiotensin II, tumor necrosis factor α and interleukin-1β upregulated OPG expression in VSMC. Moreover, inhibition of phosphatidylinositol 3-kinase/Akt or P38-signal pathway abrogated PDGF-induced OPG expression. Our results suggest that OPG may be an important determinant of vascular homeostasis.

Original languageEnglish (US)
Pages (from-to)180-184
Number of pages5
JournalFEBS Letters
Volume521
Issue number1-3
DOIs
StatePublished - Jun 19 2002
Externally publishedYes

Keywords

  • Gene expression
  • Osteoprotegerin
  • Platelet-derived growth factor
  • Signaling pathway
  • Vascular smooth muscle cell

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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