Abstract
Aim: The treatment of non-small-cell lung cancer has changed after the development of the immune checkpoint inhibitors. Although the most studied biomarker is PD-L1 expression, its clinical significance is still debatable. In this article, we show the updated survival analysis of all published data. Methods: We searched in network and conference data sources for relevant clinical studies of immunotherapy for non-small-cell lung cancer that assessed the PD-L1 expression even as an exploratory analysis. The updated survival hazard ratios (HR) were included in the analysis. Results: 14 studies with 2857 patients were included (2019 treated with immunotherapy). The response rate was as higher among PD-L1-positive patients (RR: 2.19, 95% CI: 1.63-2.94). PD-L1 expression was also related to better progression-free survival (HR: 0.69, 95% CI: 0.57-0.85) and better overall survival (HR: 0.77, 95% CI: 0.67-0.89). Conclusion: PD-L1 overexpression predicts activity as well as better survival for patients treated with immune checkpoint inhibitors.
Original language | English (US) |
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Pages (from-to) | 499-506 |
Number of pages | 8 |
Journal | Immunotherapy |
Volume | 9 |
Issue number | 6 |
DOIs | |
State | Published - May 2017 |
Keywords
- PD1
- anti-PDL1
- clinical trials
- lung cancer
- meta-analysis
- nivolumab
- non-small-lung cancer
- pembrolizumab
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology