PD-1 on dendritic cells impedes innate immunity against bacterial infection

Sheng Yao, Shengdian Wang, Yuwen Zhu, Liqun Luo, Gefeng Zhu, Sarah Flies, Haiying Xu, William Ruff, Megan Broadwater, In Hak Choi, Koji Tamada, Lieping Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Programmed death one (PD-1) is an inducible molecule belonging to the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes and plays pivotal roles in the negative regulation of adaptive immune responses. We report here an unexpected finding: that PD-1 could also be induced on splenic dendritic cells (DCs) by various inflammatory stimuli. Adoptive transfer of PD-1-deficient DCs demonstrates their superior capacity to wild-type DCs in innate protection of mice against lethal infection by Listeria monocytogenes. Furthermore, PD-1-deficient mice are also more resistant to the infection than wild-type controls, even in the absence of T and B cells, accompanied by elevated production of DC-derived interleukin-12 and tumor necrosis factor-α. Our results reveal a novel role of PD-1 in the negative regulation of DC function during innate immune response.

Original languageEnglish (US)
Pages (from-to)5811-5818
Number of pages8
JournalBlood
Volume113
Issue number23
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

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