Abstract
Programmed death one (PD-1) is an inducible molecule belonging to the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes and plays pivotal roles in the negative regulation of adaptive immune responses. We report here an unexpected finding: that PD-1 could also be induced on splenic dendritic cells (DCs) by various inflammatory stimuli. Adoptive transfer of PD-1-deficient DCs demonstrates their superior capacity to wild-type DCs in innate protection of mice against lethal infection by Listeria monocytogenes. Furthermore, PD-1-deficient mice are also more resistant to the infection than wild-type controls, even in the absence of T and B cells, accompanied by elevated production of DC-derived interleukin-12 and tumor necrosis factor-α. Our results reveal a novel role of PD-1 in the negative regulation of DC function during innate immune response.
Original language | English (US) |
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Pages (from-to) | 5811-5818 |
Number of pages | 8 |
Journal | Blood |
Volume | 113 |
Issue number | 23 |
DOIs | |
State | Published - 2009 |
ASJC Scopus subject areas
- Hematology
- Biochemistry
- Cell Biology
- Immunology