PD-1 as an immune modulatory receptor

Sheng Yao, Lieping Chen

Research output: Contribution to journalArticle

Abstract

Programmed cell death 1 (PD-1) is an inducible immune modulatory receptor. Upon interaction with its ligands B7 homolog 1 (PD-L1) and B7-DC (PD-L2), PD-1 plays important roles in negative regulation of T cell responses to antigen stimulation and maintaining peripheral tolerance. In addition to the inducible expression pattern on conventional T cells, PD-1 is also found on regulatory T cells, follicular T and B cells, and antigen-presenting cells including activated dendritic cells and monocytes. Therefore, PD-1 may have a much broader functionality than expected in negative regulation of multiple arms of immune responses. In addition to cancer therapy, the manipulation of PD-1 and its ligands may hold great promise for therapeutic applications also in autoimmune and infectious diseases.

Original languageEnglish (US)
Pages (from-to)262-264
Number of pages3
JournalCancer Journal (United States)
Volume20
Issue number4
DOIs
StatePublished - 2014
Externally publishedYes

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Keywords

  • cancer therapy
  • Programmed cell death 1 (PD-1)

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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