“PCR karyotype” of monochromosomal somatic cell hybrids

Yi Ning, Mercedes Lovell, Linda D. Cooley, Olivia M. Pereira-Smith

Research output: Contribution to journalArticlepeer-review

Abstract

Following fusion of human diploid fibroblast-derived microcells with mouse A9 cells, we isolated seven monochromosomal hybrids containing a single human chromosome 2, 3, 5, 12, 15, 20, or 22. Cytogenetic analysis as well as PCR karyotyping (chromosome-specific banding pattern generated by Alu-PCR) was performed on all the hybrids. We here present, for the first time, the specific PCR karyotypes of human chromosomes 2 and 20.

Original languageEnglish (US)
Pages (from-to)758-760
Number of pages3
JournalGenomics
Volume16
Issue number3
DOIs
StatePublished - Jun 1993

ASJC Scopus subject areas

  • Genetics

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