Paving the path to HIV neurotherapy: Predicting SIV CNS disease

Research output: Contribution to journalReview article

Abstract

Abstract HIV-induced damage to the CNS remains a major challenge for over 30 million people in the world despite the successes of combined antiretroviral therapy in limiting viral replication. Predicting development and progression of HIV-associated CNS disease is crucial because prevention and early intervention could be more effective than attempts to promote repair. The SIV/macaque model is the premier platform to study HIV neuropathogenesis, including discovery of predictive factors such as neuroprotective host genes and both blood and CSF biomarkers that precede and predict development of SIV CNS disease. This report details the role of macaque MHC class I genes, longitudinal alterations in biomarkers in the circulation, and expression of inflammatory and neuronal damage markers in CSF using samples from SIV-inoculated pigtailed macaques collected during acute, asymptomatic, and terminal stages of infection.

Original languageEnglish (US)
Article number69819
Pages (from-to)303-312
Number of pages10
JournalEuropean Journal of Pharmacology
Volume759
DOIs
StatePublished - Jul 15 2015

Keywords

  • CCL2
  • CSF
  • HIV
  • IL-6
  • MHC class I
  • Pigtailed macaque
  • Platelets
  • SIV

ASJC Scopus subject areas

  • Pharmacology

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