TY - JOUR
T1 - Pausing on Polyribosomes
T2 - Make Way for Elongation in Translational Control
AU - Richter, Joel D.
AU - Coller, Jeff
N1 - Funding Information:
We thank Drs. Lori Lorenz, Botao Liu, and Sophie Martin for comments on the manuscript. Work from the authors’ laboratories was supported by grants from the National Institutes of Health (R01 GM46779, R01 NS079415, and U54 082013 to J.D.R. and R01 GM080465 to J.C.).
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/10/8
Y1 - 2015/10/8
N2 - Among the three phases of mRNA translation - initiation, elongation, and termination - initiation has traditionally been considered to be rate limiting and thus the focus of regulation. Emerging evidence, however, demonstrates that control of ribosome translocation (polypeptide elongation) can also be regulatory and indeed exerts a profound influence on development, neurologic disease, and cell stress. The correspondence of mRNA codon usage and the relative abundance of their cognate tRNAs is equally important for mediating the rate of polypeptide elongation. Here, we discuss recent results showing that ribosome pausing is a widely used mechanism for controlling translation and, as a result, biological transitions in health and disease.
AB - Among the three phases of mRNA translation - initiation, elongation, and termination - initiation has traditionally been considered to be rate limiting and thus the focus of regulation. Emerging evidence, however, demonstrates that control of ribosome translocation (polypeptide elongation) can also be regulatory and indeed exerts a profound influence on development, neurologic disease, and cell stress. The correspondence of mRNA codon usage and the relative abundance of their cognate tRNAs is equally important for mediating the rate of polypeptide elongation. Here, we discuss recent results showing that ribosome pausing is a widely used mechanism for controlling translation and, as a result, biological transitions in health and disease.
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U2 - 10.1016/j.cell.2015.09.041
DO - 10.1016/j.cell.2015.09.041
M3 - Review article
C2 - 26451481
AN - SCOPUS:84943742690
SN - 0092-8674
VL - 163
SP - 292
EP - 300
JO - Cell
JF - Cell
IS - 2
ER -