Pausing on Polyribosomes: Make Way for Elongation in Translational Control

Joel D. Richter, Jeff Coller

Research output: Contribution to journalReview articlepeer-review

Abstract

Among the three phases of mRNA translation - initiation, elongation, and termination - initiation has traditionally been considered to be rate limiting and thus the focus of regulation. Emerging evidence, however, demonstrates that control of ribosome translocation (polypeptide elongation) can also be regulatory and indeed exerts a profound influence on development, neurologic disease, and cell stress. The correspondence of mRNA codon usage and the relative abundance of their cognate tRNAs is equally important for mediating the rate of polypeptide elongation. Here, we discuss recent results showing that ribosome pausing is a widely used mechanism for controlling translation and, as a result, biological transitions in health and disease.

Original languageEnglish (US)
Pages (from-to)292-300
Number of pages9
JournalCell
Volume163
Issue number2
DOIs
StatePublished - Oct 8 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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