Patterns of growth and decline in lung function in Persistent Childhood Asthma

M. J. McGeachie, K. P. Yates, X. Zhou, F. Guo, A. L. Sternberg, M. L. Van Natta, R. A. Wise, S. J. Szefler, S. Sharma, A. T. Kho, M. H. Cho, D. C. Croteau-Chonka, P. J. Castaldi, G. Jain, A. Sanyal, Y. Zhan, B. R. Lajoie, J. Dekker, J. Stamatoyannopoulos, R. A. Covar & 17 others R. S. Zeiger, N. F. Adkinson, P. V. Williams, H. W. Kelly, H. Grasemann, J. M. Vonk, G. H. Koppelman, D. S. Postma, B. A. Raby, I. Houston, Q. Lu, A. L. Fuhlbrigge, K. G. Tantisira, E. K. Silverman, J. Tonascia, S. T. Weiss, R. C. Strunk

Research output: Contribution to journalArticle

Abstract

BACKGROUND Tracking longitudinal measurements of growth and decline in lung function in patients with persistent childhood asthma may reveal links between asthma and subsequent chronic airflow obstruction. METHODS We classified children with asthma according to four characteristic patterns of lung-function growth and decline on the basis of graphs showing forced expiratory volume in 1 second (FEV1), representing spirometric measurements performed from childhood into adulthood. Risk factors associated with abnormal patterns were also examined. To define normal values, we used FEV1 values from participants in the National Health and Nutrition Examination Survey who did not have asthma. RESULTS Of the 684 study participants, 170 (25%) had a normal pattern of lung-function growth without early decline, and 514 (75%) had abnormal patterns: 176 (26%) had reduced growth and an early decline, 160 (23%) had reduced growth only, and 178 (26%) had normal growth and an early decline. Lower baseline values for FEV1, smaller bronchodilator response, airway hyperresponsiveness at baseline, and male sex were associated with reduced growth (P

LanguageEnglish (US)
Pages1842-1852
Number of pages11
JournalNew England Journal of Medicine
Volume374
Issue number19
DOIs
StatePublished - May 12 2016

Fingerprint

Asthma
Lung
Growth
Forced Expiratory Volume
Nutrition Surveys
Bronchodilator Agents
Chronic Obstructive Pulmonary Disease
Reference Values

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Patterns of growth and decline in lung function in Persistent Childhood Asthma. / McGeachie, M. J.; Yates, K. P.; Zhou, X.; Guo, F.; Sternberg, A. L.; Van Natta, M. L.; Wise, R. A.; Szefler, S. J.; Sharma, S.; Kho, A. T.; Cho, M. H.; Croteau-Chonka, D. C.; Castaldi, P. J.; Jain, G.; Sanyal, A.; Zhan, Y.; Lajoie, B. R.; Dekker, J.; Stamatoyannopoulos, J.; Covar, R. A.; Zeiger, R. S.; Adkinson, N. F.; Williams, P. V.; Kelly, H. W.; Grasemann, H.; Vonk, J. M.; Koppelman, G. H.; Postma, D. S.; Raby, B. A.; Houston, I.; Lu, Q.; Fuhlbrigge, A. L.; Tantisira, K. G.; Silverman, E. K.; Tonascia, J.; Weiss, S. T.; Strunk, R. C.

In: New England Journal of Medicine, Vol. 374, No. 19, 12.05.2016, p. 1842-1852.

Research output: Contribution to journalArticle

McGeachie, MJ, Yates, KP, Zhou, X, Guo, F, Sternberg, AL, Van Natta, ML, Wise, RA, Szefler, SJ, Sharma, S, Kho, AT, Cho, MH, Croteau-Chonka, DC, Castaldi, PJ, Jain, G, Sanyal, A, Zhan, Y, Lajoie, BR, Dekker, J, Stamatoyannopoulos, J, Covar, RA, Zeiger, RS, Adkinson, NF, Williams, PV, Kelly, HW, Grasemann, H, Vonk, JM, Koppelman, GH, Postma, DS, Raby, BA, Houston, I, Lu, Q, Fuhlbrigge, AL, Tantisira, KG, Silverman, EK, Tonascia, J, Weiss, ST & Strunk, RC 2016, 'Patterns of growth and decline in lung function in Persistent Childhood Asthma' New England Journal of Medicine, vol 374, no. 19, pp. 1842-1852. DOI: 10.1056/NEJMoa1513737
McGeachie, M. J. ; Yates, K. P. ; Zhou, X. ; Guo, F. ; Sternberg, A. L. ; Van Natta, M. L. ; Wise, R. A. ; Szefler, S. J. ; Sharma, S. ; Kho, A. T. ; Cho, M. H. ; Croteau-Chonka, D. C. ; Castaldi, P. J. ; Jain, G. ; Sanyal, A. ; Zhan, Y. ; Lajoie, B. R. ; Dekker, J. ; Stamatoyannopoulos, J. ; Covar, R. A. ; Zeiger, R. S. ; Adkinson, N. F. ; Williams, P. V. ; Kelly, H. W. ; Grasemann, H. ; Vonk, J. M. ; Koppelman, G. H. ; Postma, D. S. ; Raby, B. A. ; Houston, I. ; Lu, Q. ; Fuhlbrigge, A. L. ; Tantisira, K. G. ; Silverman, E. K. ; Tonascia, J. ; Weiss, S. T. ; Strunk, R. C./ Patterns of growth and decline in lung function in Persistent Childhood Asthma. In: New England Journal of Medicine. 2016 ; Vol. 374, No. 19. pp. 1842-1852
@article{937b0b5306c940d28a338661b40f49b8,
title = "Patterns of growth and decline in lung function in Persistent Childhood Asthma",
abstract = "BACKGROUND Tracking longitudinal measurements of growth and decline in lung function in patients with persistent childhood asthma may reveal links between asthma and subsequent chronic airflow obstruction. METHODS We classified children with asthma according to four characteristic patterns of lung-function growth and decline on the basis of graphs showing forced expiratory volume in 1 second (FEV1), representing spirometric measurements performed from childhood into adulthood. Risk factors associated with abnormal patterns were also examined. To define normal values, we used FEV1 values from participants in the National Health and Nutrition Examination Survey who did not have asthma. RESULTS Of the 684 study participants, 170 (25\{%}) had a normal pattern of lung-function growth without early decline, and 514 (75\{%}) had abnormal patterns: 176 (26\{%}) had reduced growth and an early decline, 160 (23\{%}) had reduced growth only, and 178 (26\{%}) had normal growth and an early decline. Lower baseline values for FEV1, smaller bronchodilator response, airway hyperresponsiveness at baseline, and male sex were associated with reduced growth (P",
author = "McGeachie, {M. J.} and Yates, {K. P.} and X. Zhou and F. Guo and Sternberg, {A. L.} and {Van Natta}, {M. L.} and Wise, {R. A.} and Szefler, {S. J.} and S. Sharma and Kho, {A. T.} and Cho, {M. H.} and Croteau-Chonka, {D. C.} and Castaldi, {P. J.} and G. Jain and A. Sanyal and Y. Zhan and Lajoie, {B. R.} and J. Dekker and J. Stamatoyannopoulos and Covar, {R. A.} and Zeiger, {R. S.} and Adkinson, {N. F.} and Williams, {P. V.} and Kelly, {H. W.} and H. Grasemann and Vonk, {J. M.} and Koppelman, {G. H.} and Postma, {D. S.} and Raby, {B. A.} and I. Houston and Q. Lu and Fuhlbrigge, {A. L.} and Tantisira, {K. G.} and Silverman, {E. K.} and J. Tonascia and Weiss, {S. T.} and Strunk, {R. C.}",
year = "2016",
month = "5",
day = "12",
doi = "10.1056/NEJMoa1513737",
language = "English (US)",
volume = "374",
pages = "1842--1852",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "19",

}

TY - JOUR

T1 - Patterns of growth and decline in lung function in Persistent Childhood Asthma

AU - McGeachie,M. J.

AU - Yates,K. P.

AU - Zhou,X.

AU - Guo,F.

AU - Sternberg,A. L.

AU - Van Natta,M. L.

AU - Wise,R. A.

AU - Szefler,S. J.

AU - Sharma,S.

AU - Kho,A. T.

AU - Cho,M. H.

AU - Croteau-Chonka,D. C.

AU - Castaldi,P. J.

AU - Jain,G.

AU - Sanyal,A.

AU - Zhan,Y.

AU - Lajoie,B. R.

AU - Dekker,J.

AU - Stamatoyannopoulos,J.

AU - Covar,R. A.

AU - Zeiger,R. S.

AU - Adkinson,N. F.

AU - Williams,P. V.

AU - Kelly,H. W.

AU - Grasemann,H.

AU - Vonk,J. M.

AU - Koppelman,G. H.

AU - Postma,D. S.

AU - Raby,B. A.

AU - Houston,I.

AU - Lu,Q.

AU - Fuhlbrigge,A. L.

AU - Tantisira,K. G.

AU - Silverman,E. K.

AU - Tonascia,J.

AU - Weiss,S. T.

AU - Strunk,R. C.

PY - 2016/5/12

Y1 - 2016/5/12

N2 - BACKGROUND Tracking longitudinal measurements of growth and decline in lung function in patients with persistent childhood asthma may reveal links between asthma and subsequent chronic airflow obstruction. METHODS We classified children with asthma according to four characteristic patterns of lung-function growth and decline on the basis of graphs showing forced expiratory volume in 1 second (FEV1), representing spirometric measurements performed from childhood into adulthood. Risk factors associated with abnormal patterns were also examined. To define normal values, we used FEV1 values from participants in the National Health and Nutrition Examination Survey who did not have asthma. RESULTS Of the 684 study participants, 170 (25%) had a normal pattern of lung-function growth without early decline, and 514 (75%) had abnormal patterns: 176 (26%) had reduced growth and an early decline, 160 (23%) had reduced growth only, and 178 (26%) had normal growth and an early decline. Lower baseline values for FEV1, smaller bronchodilator response, airway hyperresponsiveness at baseline, and male sex were associated with reduced growth (P

AB - BACKGROUND Tracking longitudinal measurements of growth and decline in lung function in patients with persistent childhood asthma may reveal links between asthma and subsequent chronic airflow obstruction. METHODS We classified children with asthma according to four characteristic patterns of lung-function growth and decline on the basis of graphs showing forced expiratory volume in 1 second (FEV1), representing spirometric measurements performed from childhood into adulthood. Risk factors associated with abnormal patterns were also examined. To define normal values, we used FEV1 values from participants in the National Health and Nutrition Examination Survey who did not have asthma. RESULTS Of the 684 study participants, 170 (25%) had a normal pattern of lung-function growth without early decline, and 514 (75%) had abnormal patterns: 176 (26%) had reduced growth and an early decline, 160 (23%) had reduced growth only, and 178 (26%) had normal growth and an early decline. Lower baseline values for FEV1, smaller bronchodilator response, airway hyperresponsiveness at baseline, and male sex were associated with reduced growth (P

UR - http://www.scopus.com/inward/record.url?scp=84966480721&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966480721&partnerID=8YFLogxK

U2 - 10.1056/NEJMoa1513737

DO - 10.1056/NEJMoa1513737

M3 - Article

VL - 374

SP - 1842

EP - 1852

JO - New England Journal of Medicine

T2 - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 19

ER -