Patterns of genetic variation in mendelian and complex traits

Michael E. Zwick, David J. Cutler, Aravinda Chakravarti

Research output: Contribution to journalReview articlepeer-review

Abstract

This review discusses the prospects for understanding the genetic basis of complex traits in humans. We take the view that work done on Drosophila melanogaster can serve as a model for understanding complex traits in humans, and the literature on this model system, as well as on humans, is reviewed. The prospects for success in understanding the genetic basis of complex traits depend, in part, on the nature of the forces acting on genetic variation. We suggest that different experimental approaches should be undertaken for traits caused by common genetic variants versus those arising from rare genetic variants.

Original languageEnglish (US)
Pages (from-to)387-407
Number of pages21
JournalAnnual Review of Genomics and Human Genetics
Volume1
Issue number2000
DOIs
StatePublished - 2000

Keywords

  • Drosophila sensory bristles
  • Human complex traits
  • Single nucleotide polymorphisms (SNPs)

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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