Patterns of failure after pancreaticoduodenectomy for ampullary carcinoma

C. G. Willett, A. L. Warshaw, K. Convery, C. C. Compton

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Abstract

The clinical courses of 41 patients with ampullary carcinoma were retrospectively reviewed to determine patterns of failure after resection. The five year actuarial local control and overall survival rates of 29 patients undergoing only pancreaticoduodenectomy were 69 and 55 percent, respectively. For 12 patients with 'low risk' pathologic features (tumors limited to the ampulla or duodenum, well or moderately well-differentiated histologic factors, uninvolved lymph nodes or resection margins), the five year actuarial local control and survival rate was 100 and 80 percent, respectively. Adjuvant treatment may be unnecessary for this favorable subset of patients. On the other hand, the five year actuarial local control and survival after pancreaticoduodenectomy of 17 patients with 'high-risk' pathologic features (tumors invasive of the pancreas, poorly differentiated histologic findings, involved lymph nodes or resection margins) was only 50 and 38 percent, respectively (p

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalSurgery Gynecology and Obstetrics
Volume176
Issue number1
StatePublished - 1993
Externally publishedYes

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ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Surgery

Cite this

Willett, C. G., Warshaw, A. L., Convery, K., & Compton, C. C. (1993). Patterns of failure after pancreaticoduodenectomy for ampullary carcinoma. Surgery Gynecology and Obstetrics, 176(1), 33-38.