Patterns of cerebral atrophy in HIV–1–infected individuals: Results of a quantitative MRI analysis

Gerald J. Dal Pan, Julie McArthur, Elizabeth H. Aylward, Ola A Selnes, T. E. Nance-Sproson, A. J. Kumar, E. D. Mellits, J. C. Mc Arthur

Research output: Contribution to journalArticlepeer-review


Article abstract Cerebral atrophy is a common radiologie manifestation of HIV dementia. To evaluate the relationship between cognitive impairment and cerebral atrophy, adjusting for age and immune status, we used standardized planimetry to measure the ventricle–brain ratio (VBR) and the bifrontal (BFR) and bicaudate (BCR) ratios, three measures of cerebral atrophy. We analyzed cranial MRIs of 23 HIV–1–seronegative controls (SN) and 116 HIV–1–infected individuals. Of the HIV–1–seropositive individuals, 37 had HIV dementia (DM group), 40 had neurologic or neuropsychological abnormalities insufficient for HIV dementia (NP+ group), and 39 were neurologically normal (NML group). We performed comparisons using analysis of covariance with correction for multiple comparisons. Both the VBR, a general measure of overall cerebral atrophy, and the BCR, a measure of atrophy in the region of the caudate nucleus, are significantly associated with dementia. The association is stronger for BCR enlargement than for VBR enlargement, suggesting that selective caudate region atrophy is associated with HIV dementia. These results indicate that overall cerebral atrophy and prominent caudate region atrophy are important radiographie features of HIV dementia.

Original languageEnglish (US)
Pages (from-to)2125-2130
Number of pages6
Issue number11
StatePublished - Nov 1992

ASJC Scopus subject areas

  • Clinical Neurology


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