Patterns of cd4+ cell changes after HIV-1 infection indicate the existence of a codeterminant of aids

Roger Detels, Patricia A. English, Janis V. Giorgi, Barbara R. Visscher, John L. Fahey, Jeremy M.G. Taylor, Janice P. Dudley, Parunag Nishanian, Alvaro Muñoz, John P. Phair, B. Frank Polk, Charles R. Rinaldo

Research output: Contribution to journalArticle

Abstract

Successive interval slopes of CD4+ cells each constructed from levels at three consecutive 6 month visits were compared over 3 years of follow-up among 565 persistently HIV-1 antibody-positive, 326 persistently antibody-negative, and 51 seroconverting homosexual men who had at least 500 CD4+ cells/mm3 at baseline and completed the first three 6 month visits. “Change” was defined as a difference between two successive interval slopes. Sixty-two percent of seroconverters meeting these criteria experienced a shift in one or more of their successive CD4+ interval slopes, the majority (56%) from a level slope to a negative slope (decreasing numbers of CD4+ cells), a significantly greater proportion than that observed among seronegatives (30%, p <0.0001). Fifty-eight percent of the seropositives maintained level interval slopes over the 3 years of follow-up. The majority (59%) of those men experiencing a shift went from a level to a negative interval slope, a significantly greater proportion than observed among seronegatives (30%, p <0.0001). The observed patterns of change in interval slopes are consistent with the laboratory observation that CD4+ cells must be activated to replicate HIV-1. The use of the interval slope strategy provides a method to identify a temporal focal point at which to examine possible codeterminants that trigger the production of HIV-1 and the subsequent decline in CD4+ cells.

Original languageEnglish (US)
Pages (from-to)390-395
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume1
Issue number4
StatePublished - Aug 1988
Externally publishedYes

Keywords

  • AIDS
  • HIV-1
  • Immunology
  • T cells

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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    Detels, R., English, P. A., Giorgi, J. V., Visscher, B. R., Fahey, J. L., Taylor, J. M. G., Dudley, J. P., Nishanian, P., Muñoz, A., Phair, J. P., Polk, B. F., & Rinaldo, C. R. (1988). Patterns of cd4+ cell changes after HIV-1 infection indicate the existence of a codeterminant of aids. Journal of Acquired Immune Deficiency Syndromes, 1(4), 390-395.