Patterns of brain reorganization subsequent to left fusiform damage: FMRI evidence from visual processing of words and pseudowords, faces and objects

Kyrana Tsapkini, Manuel Vindiola, Brenda Rapp

Research output: Contribution to journalArticle

Abstract

Little is known about the neural reorganization that takes place subsequent to lesions that affect orthographic processing (reading and/or spelling). We report on an fMRI investigation of an individual with a left mid-fusiform resection that affected both reading and spelling (Tsapkini & Rapp, 2010). To investigate possible patterns of functional reorganization, we compared the behavioral and neural activation patterns of this individual with those of a group of control participants for the tasks of silent reading of words and pseudowords and the passive viewing of faces and objects, all tasks that typically recruit the inferior temporal lobes. This comparison was carried out with methods that included a novel application of Mahalanobis distance statistics, and revealed: (1) normal behavioral and neural responses for face and object processing, (2) evidence of neural reorganization bilaterally in the posterior fusiform that supported normal performance in pseudoword reading and which contributed to word reading (3) evidence of abnormal recruitment of the bilateral anterior temporal lobes indicating compensatory (albeit insufficient) recruitment of mechanisms for circumventing the word reading deficit.

Original languageEnglish (US)
Pages (from-to)1357-1372
Number of pages16
JournalNeuroImage
Volume55
Issue number3
DOIs
StatePublished - Apr 1 2011

Keywords

  • Anterior temporal lobe
  • Functional reorganization
  • Fusiform gyrus
  • Mahalanobis
  • Reading

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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