Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human

Otilia Obreja, Matthias Ringkamp, Barbara Namer, Elmar Forsch, Andreas Klusch, Roman Rukwied, Marlen Petersen, Martin Schmelz

Research output: Contribution to journalArticle

Abstract

Activity-dependent slowing of conduction velocity (ADS) differs between classes of human nociceptors. These differences likely reflect particular expression and use-dependent slow inactivation of axonal ion channels and other mechanisms governing axonal excitability. In this study, we compared ADS of porcine and human cutaneous C-fibers. Extracellular recordings were performed from peripheral nerves, using teased fiber technique in pigs and microneurography in humans. We assessed electrically-induced conduction changes and responsiveness to natural stimuli. In both species, the group of mechano-insensitive C-fibers showed the largest conduction slowing (∼30%) upon electrical stimulation (2 Hz for 3 min). In addition, we found mechano-insensitive cold nociceptors in pig that slowed only minimally (

Original languageEnglish (US)
Pages (from-to)59-69
Number of pages11
JournalPain
Volume148
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Nociceptors
Unmyelinated Nerve Fibers
Swine
Ion Channels
Peripheral Nerves
Electric Stimulation
Skin

Keywords

  • Activity-dependent conduction slowing
  • Axonal conduction
  • Electrophysiology
  • Microneurography
  • Nociceptor
  • Skin

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine
  • Neurology
  • Pharmacology

Cite this

Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human. / Obreja, Otilia; Ringkamp, Matthias; Namer, Barbara; Forsch, Elmar; Klusch, Andreas; Rukwied, Roman; Petersen, Marlen; Schmelz, Martin.

In: Pain, Vol. 148, No. 1, 01.2010, p. 59-69.

Research output: Contribution to journalArticle

Obreja, Otilia ; Ringkamp, Matthias ; Namer, Barbara ; Forsch, Elmar ; Klusch, Andreas ; Rukwied, Roman ; Petersen, Marlen ; Schmelz, Martin. / Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human. In: Pain. 2010 ; Vol. 148, No. 1. pp. 59-69.
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