TY - JOUR
T1 - Patterns and Predictors of Physical Functional Disability at 5 to 10 Years After Heart Transplantation
AU - Grady, Kathleen L.
AU - Naftel, David C.
AU - Young, James B.
AU - Pelegrin, Dave
AU - Czerr, Jennifer
AU - Higgins, Robert
AU - Heroux, Alain
AU - Rybarczyk, Bruce
AU - McLeod, Mary
AU - Kobashigawa, Jon
AU - Chait, Julie
AU - White-Williams, Connie
AU - Myers, Susan
AU - Kirklin, James K.
N1 - Funding Information:
This research was funded by the NIH (National Institute of Nursing Research, R01 #NR005200); a grant-in-aid from the College of Nursing, Rush University; and intramural funding from the Rush Heart Institute, Rush University Medical Center. Quality of life
PY - 2007/11
Y1 - 2007/11
N2 - Background: Researchers have not examined relationships between perception of physical functional disability and demographic, clinical, and psychological variables at 5 to 10 years after heart transplantation. Therefore, the purposes of this study were to describe physical functional disability over time and identify predictors of physical functional disability from 5 to 10 years after heart transplantation. Methods: The study enrolled 555 patients who were between 5 and 10 years post-heart transplant (age, 54 ± 9 years; 78% male, 88% white, 79% married). Patients completed 6 instruments that measure physical functional disability and factors that may impact physical functional disability. Statistical analyses included calculation of frequencies, means ± standard deviation (plotted over time), Pearson correlation coefficients, and multiple regression coupled with repeated measures. Results: Between 5 and 10 years after heart transplantation, physical functional disability was low, and 34% to 45% of patients reported having no functional disability. More physical functional disability was associated with having more symptoms, having depression/mood/negative affect and lower use of negative coping strategies, having more comorbidities and more specific comorbidities (e.g., more orthopedic problems and diabetes); higher New York Heart Association functional class; having more acute rejection, infection, or cardiac allograft vasculopathy; being female, older, less educated, and unemployed; higher body mass index; and more hospital readmissions (explaining 46% of variance [F = 84.75, p < 0.0001]). Conclusions: Demographic, clinical, and psychological factors were significantly related to physical functional disability. Knowledge of these factors provides the basis for development of therapeutic plans of care.
AB - Background: Researchers have not examined relationships between perception of physical functional disability and demographic, clinical, and psychological variables at 5 to 10 years after heart transplantation. Therefore, the purposes of this study were to describe physical functional disability over time and identify predictors of physical functional disability from 5 to 10 years after heart transplantation. Methods: The study enrolled 555 patients who were between 5 and 10 years post-heart transplant (age, 54 ± 9 years; 78% male, 88% white, 79% married). Patients completed 6 instruments that measure physical functional disability and factors that may impact physical functional disability. Statistical analyses included calculation of frequencies, means ± standard deviation (plotted over time), Pearson correlation coefficients, and multiple regression coupled with repeated measures. Results: Between 5 and 10 years after heart transplantation, physical functional disability was low, and 34% to 45% of patients reported having no functional disability. More physical functional disability was associated with having more symptoms, having depression/mood/negative affect and lower use of negative coping strategies, having more comorbidities and more specific comorbidities (e.g., more orthopedic problems and diabetes); higher New York Heart Association functional class; having more acute rejection, infection, or cardiac allograft vasculopathy; being female, older, less educated, and unemployed; higher body mass index; and more hospital readmissions (explaining 46% of variance [F = 84.75, p < 0.0001]). Conclusions: Demographic, clinical, and psychological factors were significantly related to physical functional disability. Knowledge of these factors provides the basis for development of therapeutic plans of care.
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U2 - 10.1016/j.healun.2007.08.001
DO - 10.1016/j.healun.2007.08.001
M3 - Article
C2 - 18022086
AN - SCOPUS:36049013041
SN - 1053-2498
VL - 26
SP - 1182
EP - 1191
JO - Journal of Heart and Lung Transplantation
JF - Journal of Heart and Lung Transplantation
IS - 11
ER -