TY - JOUR
T1 - Patterning, specification, and differentiation in the developing hypothalamus
AU - Bedont, Joseph L.
AU - Newman, Elizabeth A.
AU - Blackshaw, Seth
N1 - Publisher Copyright:
© 2015 Wiley Periodicals, Inc.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Owing to its complex structure and highly diverse cell populations, the study of hypothalamic development has historically lagged behind that of other brain regions. However, in recent years, a greatly expanded understanding of hypothalamic gene expression during development has opened up new avenues of investigation. In this review, we synthesize existing work to present a holistic picture of hypothalamic development from early induction and patterning through nuclear specification and differentiation, with a particular emphasis on determination of cell fate. We will also touch on special topics in the field including the prosomere model, adult neurogenesis, and integration of migratory cells originating outside the hypothalamic neuroepithelium, and how these topics relate to our broader theme.
AB - Owing to its complex structure and highly diverse cell populations, the study of hypothalamic development has historically lagged behind that of other brain regions. However, in recent years, a greatly expanded understanding of hypothalamic gene expression during development has opened up new avenues of investigation. In this review, we synthesize existing work to present a holistic picture of hypothalamic development from early induction and patterning through nuclear specification and differentiation, with a particular emphasis on determination of cell fate. We will also touch on special topics in the field including the prosomere model, adult neurogenesis, and integration of migratory cells originating outside the hypothalamic neuroepithelium, and how these topics relate to our broader theme.
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U2 - 10.1002/wdev.187
DO - 10.1002/wdev.187
M3 - Review article
C2 - 25820448
AN - SCOPUS:84930503865
SN - 1759-7684
VL - 4
SP - 445
EP - 468
JO - Wiley Interdisciplinary Reviews: Developmental Biology
JF - Wiley Interdisciplinary Reviews: Developmental Biology
IS - 5
ER -