Pattern recognition analysis of anterior cingulated cortex blood flow to classify depression polarity

J. R.C. Almeida; J. Mourao-Miranda; H. J. Aizenstein; A. Versace; F. A. Kozel; H. Lu; A. Marquand; E. J. LaBarbara; M. Brammer; M. Trivedi; D. J. Kupfer; M. L. Phillips

doi:10.1192/bjp.bp.112.122838

Pattern recognition analysis of anterior cingulated cortex blood flow to classify depression polarity

J. R.C. Almeida, J. Mourao-Miranda, H. J. Aizenstein, A. Versace, F. A. Kozel, H. Lu, A. Marquand, E. J. LaBarbara, M. Brammer, M. Trivedi, D. J. Kupfer, M. L. Phillips

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Differentiating bipolar from recurrent unipolar depression is a major clinical challenge. In 18 healthy females and 36 females in a depressive episode - 18 with bipolar disorder type I, 18 with recurrent unipolar depression - we applied pattern recognition analysis using subdivisions of anterior cingulate cortex (ACC) blood flow at rest, measured with arterial spin labelling. Subgenual ACC blood flow classified unipolar v. bipolar depression with 81% accuracy (83% sensitivity, 78% specificity).

Original language	English (US)
Pages (from-to)	310-311
Number of pages	2
Journal	British Journal of Psychiatry
Volume	203
Issue number	4
DOIs	https://doi.org/10.1192/bjp.bp.112.122838
State	Published - Oct 2013
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health

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Almeida, J. R. C., Mourao-Miranda, J., Aizenstein, H. J., Versace, A., Kozel, F. A., Lu, H., Marquand, A., LaBarbara, E. J., Brammer, M., Trivedi, M., Kupfer, D. J., & Phillips, M. L. (2013). Pattern recognition analysis of anterior cingulated cortex blood flow to classify depression polarity. British Journal of Psychiatry, 203(4), 310-311. https://doi.org/10.1192/bjp.bp.112.122838

Almeida, JRC, Mourao-Miranda, J, Aizenstein, HJ, Versace, A, Kozel, FA, Lu, H, Marquand, A, LaBarbara, EJ, Brammer, M, Trivedi, M, Kupfer, DJ & Phillips, ML 2013, 'Pattern recognition analysis of anterior cingulated cortex blood flow to classify depression polarity', British Journal of Psychiatry, vol. 203, no. 4, pp. 310-311. https://doi.org/10.1192/bjp.bp.112.122838

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abstract = "Differentiating bipolar from recurrent unipolar depression is a major clinical challenge. In 18 healthy females and 36 females in a depressive episode - 18 with bipolar disorder type I, 18 with recurrent unipolar depression - we applied pattern recognition analysis using subdivisions of anterior cingulate cortex (ACC) blood flow at rest, measured with arterial spin labelling. Subgenual ACC blood flow classified unipolar v. bipolar depression with 81% accuracy (83% sensitivity, 78% specificity).",

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year = "2013",

month = oct,

doi = "10.1192/bjp.bp.112.122838",

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AU - Mourao-Miranda, J.

AU - Aizenstein, H. J.

AU - Versace, A.

AU - Kozel, F. A.

AU - Lu, H.

AU - Marquand, A.

AU - LaBarbara, E. J.

AU - Brammer, M.

AU - Trivedi, M.

AU - Kupfer, D. J.

AU - Phillips, M. L.

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AB - Differentiating bipolar from recurrent unipolar depression is a major clinical challenge. In 18 healthy females and 36 females in a depressive episode - 18 with bipolar disorder type I, 18 with recurrent unipolar depression - we applied pattern recognition analysis using subdivisions of anterior cingulate cortex (ACC) blood flow at rest, measured with arterial spin labelling. Subgenual ACC blood flow classified unipolar v. bipolar depression with 81% accuracy (83% sensitivity, 78% specificity).

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Pattern recognition analysis of anterior cingulated cortex blood flow to classify depression polarity

Abstract

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