Pattern identification in time-course gene expression data with the CoGAPS matrix factorization

Elana J. Fertig, Genevieve Stein-O'Brien, Andrew Jaffe, Carlo Colantuoni

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Patterns in time-course gene expression data can represent the biological processes that are active over the measured time period. However, the orthogonality constraint in standard pattern-finding algorithms, including notably principal components analysis (PCA), confounds expression changes resulting from simultaneous, non-orthogonal biological processes. Previously, we have shown that Markov chain Monte Carlo nonnegative matrix factorization algorithms are particularly adept at distinguishing such concurrent patterns. One such matrix factorization is implemented in the software package CoGAPS. We describe the application of this software and several technical considerations for identification of age-related patterns in a public, prefrontal cortex gene expression dataset.

Original languageEnglish (US)
Title of host publicationGene Function Analysis
PublisherHumana Press Inc.
Pages87-112
Number of pages26
ISBN (Print)9781627037204
DOIs
StatePublished - 2014

Publication series

NameMethods in Molecular Biology
Volume1101
ISSN (Print)1064-3745

Keywords

  • Gene expression
  • Markov Chain Monte Carlo
  • Nonnegative matrix factorization

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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