Patients with Fanconi anemia and AML have different cytogenetic clones than de novo cases of AML

Andrzej Rochowski; Susan B. Olson; Todd A. Alonzo; Robert B. Gerbing; Beverly J. Lange; Blanche P. Alter

doi:10.1002/pbc.24168

Patients with Fanconi anemia and AML have different cytogenetic clones than de novo cases of AML

Andrzej Rochowski, Susan B. Olson, Todd A. Alonzo, Robert B. Gerbing, Beverly J. Lange, Blanche P. Alter

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Specific cytogenetic clones might distinguish patients with unrecognized Fanconi anemia (FA) who present with acute myeloid leukemia (AML) from those with sporadic AML. Cytogenetic reports in literature cases of FA and AML were compared with de novo cases enrolled on CCG-2961. Gain of 1q, gain of 3q, monosomy 7, deleted 7q, gain of 13q, and deleted 20q were more frequent in FA AML; t(8;21), trisomy 8, t(9;11), t(6;9), and inversion 16 were exclusive to de novo AML cases. Observation of the FA AML cytogenetic clonal patterns should raise suspicion of an underlying leukemia predisposition syndrome and influence management.

Original language	English (US)
Pages (from-to)	922-924
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	59
Issue number	5
DOIs	https://doi.org/10.1002/pbc.24168
State	Published - Nov 2012
Externally published	Yes

Keywords

Acute myelogenous leukemia
Clones
Cytogenetics
Fanconi anemia
Sporadic AML

ASJC Scopus subject areas

Oncology
Pediatrics, Perinatology, and Child Health
Hematology

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10.1002/pbc.24168

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title = "Patients with Fanconi anemia and AML have different cytogenetic clones than de novo cases of AML",

abstract = "Specific cytogenetic clones might distinguish patients with unrecognized Fanconi anemia (FA) who present with acute myeloid leukemia (AML) from those with sporadic AML. Cytogenetic reports in literature cases of FA and AML were compared with de novo cases enrolled on CCG-2961. Gain of 1q, gain of 3q, monosomy 7, deleted 7q, gain of 13q, and deleted 20q were more frequent in FA AML; t(8;21), trisomy 8, t(9;11), t(6;9), and inversion 16 were exclusive to de novo AML cases. Observation of the FA AML cytogenetic clonal patterns should raise suspicion of an underlying leukemia predisposition syndrome and influence management.",

keywords = "Acute myelogenous leukemia, Clones, Cytogenetics, Fanconi anemia, Sporadic AML",

author = "Andrzej Rochowski and Olson, {Susan B.} and Alonzo, {Todd A.} and Gerbing, {Robert B.} and Lange, {Beverly J.} and Alter, {Blanche P.}",

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T1 - Patients with Fanconi anemia and AML have different cytogenetic clones than de novo cases of AML

AU - Rochowski, Andrzej

AU - Olson, Susan B.

AU - Alonzo, Todd A.

AU - Gerbing, Robert B.

AU - Lange, Beverly J.

AU - Alter, Blanche P.

PY - 2012/11

Y1 - 2012/11

N2 - Specific cytogenetic clones might distinguish patients with unrecognized Fanconi anemia (FA) who present with acute myeloid leukemia (AML) from those with sporadic AML. Cytogenetic reports in literature cases of FA and AML were compared with de novo cases enrolled on CCG-2961. Gain of 1q, gain of 3q, monosomy 7, deleted 7q, gain of 13q, and deleted 20q were more frequent in FA AML; t(8;21), trisomy 8, t(9;11), t(6;9), and inversion 16 were exclusive to de novo AML cases. Observation of the FA AML cytogenetic clonal patterns should raise suspicion of an underlying leukemia predisposition syndrome and influence management.

AB - Specific cytogenetic clones might distinguish patients with unrecognized Fanconi anemia (FA) who present with acute myeloid leukemia (AML) from those with sporadic AML. Cytogenetic reports in literature cases of FA and AML were compared with de novo cases enrolled on CCG-2961. Gain of 1q, gain of 3q, monosomy 7, deleted 7q, gain of 13q, and deleted 20q were more frequent in FA AML; t(8;21), trisomy 8, t(9;11), t(6;9), and inversion 16 were exclusive to de novo AML cases. Observation of the FA AML cytogenetic clonal patterns should raise suspicion of an underlying leukemia predisposition syndrome and influence management.

KW - Acute myelogenous leukemia

KW - Clones

KW - Cytogenetics

KW - Fanconi anemia

KW - Sporadic AML

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Patients with Fanconi anemia and AML have different cytogenetic clones than de novo cases of AML

Abstract

Keywords

ASJC Scopus subject areas

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