Patients with Chronic Diarrhea

Anne B. Ballinger, Ana Maria Cevallos, Michael L. Clark, Mario Cottone, Rita Aiala, Roberto di Mitri, Larry Eisenberg, Mark Donowitz, Freddie Kokke, Roxan Saidi

Research output: Contribution to journalLetterpeer-review


To the Editor: In the review article by Donowitz et al. (March 16 issue),1 there is no mention of measuring serum or red-cell folate, serum B12, or autoantibodies in the evaluation of patients with chronic diarrhea. These tests are readily available and inexpensive, and the presence of a low concentration of red-cell folate or antiendomysial or antireticulin antibodies would alert the investigator to the possibility of celiac disease at an early stage. Folate deficiency is almost invariably present in patients with untreated celiac disease, and antiendomysial antibodies are present in 90 to 100 percent of them.2,3 Furthermore,.

Original languageEnglish (US)
Pages (from-to)257-258
Number of pages2
JournalNew England Journal of Medicine
Issue number4
StatePublished - Jul 27 1995

ASJC Scopus subject areas

  • Medicine(all)


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