Patients' and physicians' interpretation of chemotherapy-induced peripheral neurotoxicity

the CI-PeriNomS Group

Research output: Contribution to journalArticle

Abstract

To test if and how chemotherapy-induced peripheral neurotoxicity (CIPN) is perceived differently by patients and physicians, making assessment and interpretation challenging. We performed a secondary analysis of the CI-PeriNomS study which included 281 patients with stable CIPN. We tested: (a) the association between patients' perception of activity limitation in performing eight common tasks and neurological impairment and (b) how the responses to questions related to these daily activities are interpreted by the treating oncologist. To achieve this, we compared patients' perception of their activity limitation with neurological assessment and the oncologists' blind interpretation. Distribution of the scores attributed by oncologists to each daily life maximum limitation (“impossible”) generated three groups: Group 1 included limitations oncologists attributed mainly to motor impairment; Group 2 ones mainly attributed to sensory impairment and Group 3 ones with uncertain motor and sensory impairment. Only a subset of questions showed a significant trend between severity in subjective limitation, reported by patients, and neurological impairment. In Group 1, neurological examination confirmed motor impairment in only 51%-65% of patients; 76%-78% of them also had vibration perception impairment. In Group 2, sensory impairment ranged from 84% to 100%; some degree of motor impairment occurred in 43%-56% of them. In Group 3 strength reduction was observed in 49%-50% and sensory perception was altered in up to 82%. Interpretation provided by the panel of experienced oncologists was inconsistent with the neurological impairment. These observations highlight the need of a core set of outcome measures for future CIPN trials.

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalJournal of the Peripheral Nervous System
Volume24
Issue number1
DOIs
StatePublished - Mar 1 2019

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Physicians
Drug Therapy
Neurologic Examination
Vibration
Outcome Assessment (Health Care)
Oncologists

Keywords

  • assessment
  • chemotherapy
  • neurotoxicity
  • patient reported outcome measures
  • side effects

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Patients' and physicians' interpretation of chemotherapy-induced peripheral neurotoxicity. / the CI-PeriNomS Group.

In: Journal of the Peripheral Nervous System, Vol. 24, No. 1, 01.03.2019, p. 111-119.

Research output: Contribution to journalArticle

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AU - Postma, Tjeerd J.

AU - Rossi, Emanela

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AU - Pace, Andrea

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AU - Lalisang, Roy I.

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AU - Koeppen, Susanne

AU - Kerrigan, Simon

AU - Schenone, Angelo

AU - Grisold, Wolfgang

AU - Mazzeo, Anna

AU - Padua, Luca

AU - Dorsey, Susan G.

AU - Penas-Prado, Marta

AU - Valsecchi, Maria G.

AU - Faber, C. G.

AU - Frigeni, B.

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AU - Mattavelli, L.

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AU - Cortinovis, D.

AU - Galiè, E.

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AU - Salvalaggio, A.

AU - Ruiz, M.

AU - Vanhoutte, E. K.

AU - Boogerd, W.

AU - Hense, J.

AU - Grant, R.

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AU - Reni, L.

AU - Demichelis, C.

AU - Pessino, A.

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AU - Ghigliotti, I.

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KW - chemotherapy

KW - neurotoxicity

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