Patient-reported outcomes in the practice-based opportunities for weight reduction (POWER) trial

R. R. Rubin, M. Peyrot, N. Y. Wang, J. W. Coughlin, G. J. Jerome, S. L. Fitzpatrick, W. L. Bennett, A. Dalcin, G. Daumit, N. Durkin, Y. T. Chang, H. C. Yeh, T. A. Louis, L. J. Appel

Research output: Contribution to journalArticlepeer-review


Purpose: To evaluate effects of two behavioral weight-loss interventions (in-person, remote) on health-related quality of life (HRQOL) compared to a control intervention. Methods: Four hundred and fifty-one obese US adults with at least one cardiovascular risk factor completed five measures of HRQOL and depression: MOS SF-12 physical component summary (PCS) and mental component summary; EuroQoL-5 dimensions single index and visual analog scale; PHQ-8 depression symptoms; and PSQI sleep quality scores at baseline and 6 and 24 months after randomization. Change in each outcome was analyzed using outcome-specific mixed-effects models controlling for participant demographic characteristics. Results: PCS-12 scores over 24 months improved more among participants in the in-person active intervention arm than among control arm participants (P<0.05, ES = 0.21); there were no other statistically significant treatment arm differences in HRQOL change. Greater weight loss was associated with improvements in most outcomes (P<0.05 to<0.0001). Conclusions: Participants in the in-person active intervention improved more in physical function HRQOL than participants in the control arm did. Greater weight loss during the study was associated with greater improvement in all PRO except for sleep quality, suggesting that weight loss is a key factor in improving HRQOL.

Original languageEnglish (US)
Pages (from-to)2389-2398
Number of pages10
JournalQuality of Life Research
Issue number9
StatePublished - Nov 2013


  • Comparative effectiveness trial
  • Depression
  • Patient-reported outcomes
  • Quality of life
  • Weight reduction trial

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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