Patient-oriented gene set analysis for cancer mutation data

Simina M. Boca, Kenneth W Kinzler, Victor E Velculescu, Bert Vogelstein, Giovanni Parmigiani

Research output: Contribution to journalArticle

Abstract

Recent research has revealed complex heterogeneous genomic landscapes in human cancers. However, mutations tend to occur within a core group of pathways and biological processes that can be grouped into gene sets. To better understand the significance of these pathways, we have developed an approach that initially scores each gene set at the patient rather than the gene level. In mutation analysis, these patient-oriented methods are more transparent, interpretable, and statistically powerful than traditional gene-oriented methods.

Original languageEnglish (US)
Article numberR112
JournalGenome Biology
Volume11
Issue number11
DOIs
StatePublished - Nov 23 2010

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mutation
cancer
Mutation
neoplasms
gene
Genes
Neoplasms
genes
Biological Phenomena
Group Processes
biological processes
genomics
analysis
methodology
Research
method

ASJC Scopus subject areas

  • Genetics
  • Cell Biology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Patient-oriented gene set analysis for cancer mutation data. / Boca, Simina M.; Kinzler, Kenneth W; Velculescu, Victor E; Vogelstein, Bert; Parmigiani, Giovanni.

In: Genome Biology, Vol. 11, No. 11, R112, 23.11.2010.

Research output: Contribution to journalArticle

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