@article{e493b669342c487a88815865ccdec1da,
title = "Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer",
abstract = "Yao et al. generated a patient-derived organoid (PDO) biobank from patients with locally advanced rectal cancer (LARC) and reported that organoids had similar molecular profiles to those of the patient tumor and that PDOs can predict LARC patient chemoradiation responses, reinforcing their value as a companion diagnostic tool in LARC treatment.",
keywords = "chemoradiation, clinical response, organoids, predict, rectal cancer",
author = "Ye Yao and Xiaoya Xu and Lifeng Yang and Ji Zhu and Juefeng Wan and Lijun Shen and Fan Xia and Guoxiang Fu and Yun Deng and Mengxue Pan and Qiang Guo and Xiaoxue Gao and Yuanchuang Li and Xinxin Rao and Yi Zhou and Liping Liang and Yaqi Wang and Jing Zhang and Hui Zhang and Guichao Li and Lixing Zhang and Junjie Peng and Sanjun Cai and Chen Hu and Jianjun Gao and Hans Clevers and Zhen Zhang and Guoqiang Hua",
note = "Funding Information: We thank all of the patients and their families for participating in this research. We thank He Shan and Xiang Yajuan for daily support with biopsy affairs. We thank Zheng Guantao for analysis of the sequencing data. This work was supported by the National Natural Science Foundation of China ( 31470826 , 31670858 , and 81773357 ). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2020",
month = jan,
day = "2",
doi = "10.1016/j.stem.2019.10.010",
language = "English (US)",
volume = "26",
pages = "17--26.e6",
journal = "Cell stem cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "1",
}