Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

Ye Yao, Xiaoya Xu, Lifeng Yang, Ji Zhu, Juefeng Wan, Lijun Shen, Fan Xia, Guoxiang Fu, Yun Deng, Mengxue Pan, Qiang Guo, Xiaoxue Gao, Yuanchuang Li, Xinxin Rao, Yi Zhou, Liping Liang, Yaqi Wang, Jing Zhang, Hui Zhang, Guichao LiLixing Zhang, Junjie Peng, Sanjun Cai, Chen Hu, Jianjun Gao, Hans Clevers, Zhen Zhang, Guoqiang Hua

Research output: Contribution to journalArticlepeer-review

Abstract

Yao et al. generated a patient-derived organoid (PDO) biobank from patients with locally advanced rectal cancer (LARC) and reported that organoids had similar molecular profiles to those of the patient tumor and that PDOs can predict LARC patient chemoradiation responses, reinforcing their value as a companion diagnostic tool in LARC treatment.

Original languageEnglish (US)
Pages (from-to)17-26.e6
JournalCell stem cell
Volume26
Issue number1
DOIs
StatePublished - Jan 2 2020

Keywords

  • chemoradiation
  • clinical response
  • organoids
  • predict
  • rectal cancer

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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