TY - JOUR
T1 - Patient appraisal of mandarin orange didanosine
T2 - Implications for adherence and well-being
AU - Reynolds, Nancy R.
N1 - Funding Information:
We acknowledge support for this research from Bristol-Myers Squibb Oncology/Immunology and from the National Institute of Allergy and Infectious Diseases (Adult AIDS Clinical Trials Group, No. A125924, R. Fass).
PY - 1999
Y1 - 1999
N2 - Didanosine (Videx, ddl) has been shown to be an effective agent in the treatment of HIV disease. However, patients have had difficulties adhering to didanosine preparations due to taste aversion and/or associated nausea. The efficacy of didanosine may, therefore, be compromised. This is of concern to clinicians who seek to promote patient adherence to medication regimes and to foster the quality of patient well-being. In this study, focus groups were used to gather exploratory data about patient (n = 15) response to the new mandarin orange didanosine preparation. Data were audiotaped, transcribed verbatim, and systematically analyzed by the investigators using inductive techniques. Findings provide information regarding client evaluation of the new didanosine preparation and patterns of usage. Although clients generally find the mandarin orange preparation more tolerable, they describe engaging in numerous strategies aimed at attenuating what they experience as the inconvenience of taking the medication. Mental tricks, systematic restructuring of daily routines and environment, and dietary schemes were among the strategies devised by patients through trial and error to self-promote their adherence.
AB - Didanosine (Videx, ddl) has been shown to be an effective agent in the treatment of HIV disease. However, patients have had difficulties adhering to didanosine preparations due to taste aversion and/or associated nausea. The efficacy of didanosine may, therefore, be compromised. This is of concern to clinicians who seek to promote patient adherence to medication regimes and to foster the quality of patient well-being. In this study, focus groups were used to gather exploratory data about patient (n = 15) response to the new mandarin orange didanosine preparation. Data were audiotaped, transcribed verbatim, and systematically analyzed by the investigators using inductive techniques. Findings provide information regarding client evaluation of the new didanosine preparation and patterns of usage. Although clients generally find the mandarin orange preparation more tolerable, they describe engaging in numerous strategies aimed at attenuating what they experience as the inconvenience of taking the medication. Mental tricks, systematic restructuring of daily routines and environment, and dietary schemes were among the strategies devised by patients through trial and error to self-promote their adherence.
KW - AIDS
KW - Adherence
KW - Ddl
KW - Didanosine
KW - HIV
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U2 - 10.1016/S1055-3290(06)60230-6
DO - 10.1016/S1055-3290(06)60230-6
M3 - Article
C2 - 9934668
AN - SCOPUS:0032618396
SN - 1055-3290
VL - 10
SP - 35
EP - 41
JO - Journal of the Association of Nurses in AIDS Care
JF - Journal of the Association of Nurses in AIDS Care
IS - 1
ER -