Patient adherence and persistence with topical ocular hypotensive therapy in real-world practice: A comparison of bimatoprost 0.01% and travoprost Z 0.004% ophthalmic solutions

Joanna H. Campbell, Gail F. Schwartz, Britni Labounty, Jonathan W. Kowalski, Vaishali D. Patel

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Effective control of intraocular pressure is predicated upon patient compliance with pharmacotherapy. We compared patient adherence and persistence with two new ocular hypotensive formulations, using real-world utilization data. Methods: This observational cohort study employed pharmacy claims data from the Source® Lx (Wolters Kluwer Pharma Solutions) database. Patients with an initial (index) prescription for topical bimatoprost 0.01% or travoprost Z (April to June 2011) and no claim for ophthalmic prostaglandin or prostamide analogs within the previous 18 months were identified. Treatment adherence was expressed as proportion of days covered with study medication during the first 365 days after the index prescription. Treatment persistence with study medication was assessed over the first 12 months using Kaplan-Meier survival analyses, allowing a maximum 30-day gap for prescription refill. Treatment status was determined monthly over this period.Results: A total of 12,985 patients were assessed for treatment adherence, and 10,470 for t{stroke}reatment persistence. Adherence was better with bimatoprost 0.01% than with travoprost Z (mean proportion of days covered 0.540 versus [vs] 0.486, P,0.001), and more patients showed high adherence (proportion of days covered.0.80) with bimatoprost 0.01% than travoprost Z (29.1% vs 22.3%, P,0.001). Continuous 12-month persistence was higher with bimatoprost 0.01% than with travoprost Z (29.5% vs 24.2%, P,0.001). At month 12, more patients were on treatment with bimatoprost 0.01% than travoprost Z (48.8% vs 45.7%, P,0.01). Similar findings were demonstrated in cohorts of ocular hypotensive treatment-naïve patients, branded latanoprost switchers, and older patients (age $65 years), and after inclusion of patient characteristics as covariates. Conclusion: For patients with glaucoma or ocular hypertension, bimatoprost 0.01% offers compliance advantages over travoprost Z.

Original languageEnglish (US)
Pages (from-to)927-935
Number of pages9
JournalClinical Ophthalmology
Volume8
DOIs
StatePublished - May 14 2014

Keywords

  • Bimatoprost
  • Ocular hypotensive
  • Travoprost
  • Treatment compliance

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Patient adherence and persistence with topical ocular hypotensive therapy in real-world practice: A comparison of bimatoprost 0.01% and travoprost Z 0.004% ophthalmic solutions'. Together they form a unique fingerprint.

Cite this