Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations

Sonia Franco, Frederick W. Alt, John P. Manis

Research output: Contribution to journalArticle

Abstract

Guarding the genome against internal and external assaults requires the coordinated interaction of multiple cellular networks to sense, respond to, and repair breaks in chromosomal DNA. Both external factors such as ionizing radiation or internal events like oxidative damage can cause DNA double stranded breaks (DSBs) [1,2]. DSBs are also part of the normal lymphocyte developmental program where they are an integral element of the mechanisms that generate a diverse immune repertoire in the context of V(D)J and immunoglobulin heavy chain (IgH) class switch recombination (CSR) [3-5]. DSBs initiate a cascade of cellular events that direct cells to pause and properly repair potentially lethal chromosomal breaks. Errors in the repair of both general and lymphocyte-specific DSBs can lead to oncogenic chromosomal translocations [6-8]. Here, we review recent advances in understanding factors and protein complexes involved in the response to DNA DSBs with a focus on the B lymphocyte specific process of CSR.

Original languageEnglish (US)
Pages (from-to)1030-1041
Number of pages12
JournalDNA Repair
Volume5
Issue number9-10
DOIs
StatePublished - Sep 8 2006

Fingerprint

Chromosome Breakage
Genetic Translocation
DNA Breaks
Lymphocytes
Double-Stranded DNA Breaks
Genetic Recombination
Repair
Immunoglobulin Heavy Chains
DNA
Ionizing Radiation
Switches
B-Lymphocytes
Ionizing radiation
Genome
Genes
Proteins

Keywords

  • Class switch recombination
  • DNA damage response
  • Lymphoma

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations. / Franco, Sonia; Alt, Frederick W.; Manis, John P.

In: DNA Repair, Vol. 5, No. 9-10, 08.09.2006, p. 1030-1041.

Research output: Contribution to journalArticle

Franco, Sonia ; Alt, Frederick W. ; Manis, John P. / Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations. In: DNA Repair. 2006 ; Vol. 5, No. 9-10. pp. 1030-1041.
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