Pathway-specific alteration of synaptic plasticity in Tg2576 mice

Jung Hoon Jung, Kyongman An, Oh Bin Kwon, Hye Sun Kim, Joung Hun Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Various animal models of Alzheimer disease (AD) are characterized by deficits in spatial memory that are causally related to altered synaptic function and impairment of long-term potentiation (LTP) in the hippocampus. In Tg2576 AD mice, we compared LTP in 2 major hippocampal pathways, Schaffer collateral (SC) and mossy fiber (MF) pathways. Whereas LTP was completely abolished in the SC pathway of Tg2576 mice, we found no decrease in LTP induced by stimulation of the MF pathway. In fact, we found that in the MF pathway, LTP was slightly, but significantly, enhanced compared with that in the MF pathway of WT littermates. This pathway-specific impairment of LTP is not attributable to alterations in transmitter release, as indicated by an unaltered paired-pulse ratio. These results suggest that the spatial memory deficits normally seen in AD models arise primarily from LTP impairment at the SC pathway.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalMolecules and cells
Volume32
Issue number2
DOIs
StatePublished - Aug 2011
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Long-term potentiation
  • Mossy fiber pathway
  • Schaffer collateral pathway
  • Tg2576

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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