TY - JOUR
T1 - Pathophysiology of vestibular symptoms and signs
T2 - The clinical examination
AU - Zee, David S.
PY - 2006/8
Y1 - 2006/8
N2 - A challenge for the clinical neurologist is to decide which of the myriad patients with symptoms of dizziness, lightheadedness, or imbalance have a genuine vestibular disorder, be it peripheral or central. The clinical examination is often the key. A series of systematically applied, physiologically based maneuvers, designed to probe static and dynamic function of the vestibulo-ocular reflexes and the individual labyrinthine sensors, will almost always reveal the evidence of a vestibular system anomaly, which either clarifies the diagnosis or points to a need for a further evaluation.This chapter will describe these maneuvers and indicate their diagnostic usefulness. They include dynamic visual acuity, occlusive ophthalmoscopy, head impulse (rotational vestibulo-ocular reflex) and head heave (translational vestibulo-ocular reflex) testing, mastoid vibration-induced nystagmus (equivalent of a hot-water caloric stimulus in a patient with unilateral vestibular loss), hyperventilation-induced nystagmus (abnormal in fistula, craniocervical junction anomalies, compressive and demyelinating lesions, and cerebellar degenerations), Valsalva-induced nystagmus (abnormal in fistula and craniocervical junction anomalies), head-shaking-induced nystagmus (vertical nystagmus after horizontal head shaking points to a central disorder), positional nystagmus (lateral canal, posterior canal, central) and sound-induced nystagmus (superior canal dehiscence). When combined with a careful examination of eye alignment, gaze holding, saccade accuracy and speed, and smooth pursuit, a central or peripheral localization is usually possible.
AB - A challenge for the clinical neurologist is to decide which of the myriad patients with symptoms of dizziness, lightheadedness, or imbalance have a genuine vestibular disorder, be it peripheral or central. The clinical examination is often the key. A series of systematically applied, physiologically based maneuvers, designed to probe static and dynamic function of the vestibulo-ocular reflexes and the individual labyrinthine sensors, will almost always reveal the evidence of a vestibular system anomaly, which either clarifies the diagnosis or points to a need for a further evaluation.This chapter will describe these maneuvers and indicate their diagnostic usefulness. They include dynamic visual acuity, occlusive ophthalmoscopy, head impulse (rotational vestibulo-ocular reflex) and head heave (translational vestibulo-ocular reflex) testing, mastoid vibration-induced nystagmus (equivalent of a hot-water caloric stimulus in a patient with unilateral vestibular loss), hyperventilation-induced nystagmus (abnormal in fistula, craniocervical junction anomalies, compressive and demyelinating lesions, and cerebellar degenerations), Valsalva-induced nystagmus (abnormal in fistula and craniocervical junction anomalies), head-shaking-induced nystagmus (vertical nystagmus after horizontal head shaking points to a central disorder), positional nystagmus (lateral canal, posterior canal, central) and sound-induced nystagmus (superior canal dehiscence). When combined with a careful examination of eye alignment, gaze holding, saccade accuracy and speed, and smooth pursuit, a central or peripheral localization is usually possible.
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U2 - 10.1212/01.CON.0000290478.95623.8e
DO - 10.1212/01.CON.0000290478.95623.8e
M3 - Article
AN - SCOPUS:33747427747
SN - 1080-2371
VL - 12
SP - 13
EP - 32
JO - CONTINUUM Lifelong Learning in Neurology
JF - CONTINUUM Lifelong Learning in Neurology
IS - 4
ER -