Abstract
The function of the right ventricle determines the fate of patients with pulmonary hypertension. Since right heart failure is the consequence of increased afterload, a full physiological description of the cardiopulmonary unit consisting of both the right ventricle and pulmonary vascular system is required to interpret clinical data correctly. Here, we provide such a description of the unit and its components, including the functional interactions between the right ventricle and its load. This physiological description is used to provide a framework for the interpretation of right heart catheterisation data as well as imaging data of the right ventricle obtained by echocardiography or magnetic resonance imaging. Finally, an update is provided on the latest insights in the pathobiology of right ventricular failure, including key pathways of molecular adaptation of the pressure overloaded right ventricle. Based on these outcomes, future directions for research are proposed.
| Original language | English (US) |
|---|---|
| Journal | The European respiratory journal |
| Volume | 53 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2019 |
Fingerprint
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension : an update. / Vonk Noordegraaf, Anton; Chin, Kelly Marie; Haddad, François; Hassoun, Paul M; Hemnes, Anna R.; Hopkins, Susan Roberta; Kawut, Steven Mark; Langleben, David; Lumens, Joost; Naeije, Robert.
In: The European respiratory journal, Vol. 53, No. 1, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension
T2 - an update
AU - Vonk Noordegraaf, Anton
AU - Chin, Kelly Marie
AU - Haddad, François
AU - Hassoun, Paul M
AU - Hemnes, Anna R.
AU - Hopkins, Susan Roberta
AU - Kawut, Steven Mark
AU - Langleben, David
AU - Lumens, Joost
AU - Naeije, Robert
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The function of the right ventricle determines the fate of patients with pulmonary hypertension. Since right heart failure is the consequence of increased afterload, a full physiological description of the cardiopulmonary unit consisting of both the right ventricle and pulmonary vascular system is required to interpret clinical data correctly. Here, we provide such a description of the unit and its components, including the functional interactions between the right ventricle and its load. This physiological description is used to provide a framework for the interpretation of right heart catheterisation data as well as imaging data of the right ventricle obtained by echocardiography or magnetic resonance imaging. Finally, an update is provided on the latest insights in the pathobiology of right ventricular failure, including key pathways of molecular adaptation of the pressure overloaded right ventricle. Based on these outcomes, future directions for research are proposed.
AB - The function of the right ventricle determines the fate of patients with pulmonary hypertension. Since right heart failure is the consequence of increased afterload, a full physiological description of the cardiopulmonary unit consisting of both the right ventricle and pulmonary vascular system is required to interpret clinical data correctly. Here, we provide such a description of the unit and its components, including the functional interactions between the right ventricle and its load. This physiological description is used to provide a framework for the interpretation of right heart catheterisation data as well as imaging data of the right ventricle obtained by echocardiography or magnetic resonance imaging. Finally, an update is provided on the latest insights in the pathobiology of right ventricular failure, including key pathways of molecular adaptation of the pressure overloaded right ventricle. Based on these outcomes, future directions for research are proposed.
UR - http://www.scopus.com/inward/record.url?scp=85060540102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060540102&partnerID=8YFLogxK
U2 - 10.1183/13993003.01900-2018
DO - 10.1183/13993003.01900-2018
M3 - Article
C2 - 30545976
AN - SCOPUS:85060540102
VL - 53
JO - European Respiratory Journal, Supplement
JF - European Respiratory Journal, Supplement
SN - 0903-1936
IS - 1
ER -