Pathophysiology of the cardiorenal syndromes: Executive summary from the eleventh consensus conference of the acute dialysis quality initiative (ADQI)

Peter A. McCullough, John A. Kellum, Michael Haase, Christian Müller, Kevin Damman, Patrick T. Murray, Dinna Cruz, Andrew A. House, Kai M. Schmidt-Ott, Giorgio Vescovo, Sean M. Bagshaw, Eric A. Hoste, Carlos Briguori, Branko Braam, Lakhmir S. Chawla, Maria R. Costanzo, James A. Tumlin, Charles A. Herzog, Ravindra L. Mehta, Hamid RabbAndrew D. Shaw, Kai Singbartl, Claudio Ronco

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cardiorenal syndromes (CRS) have been recently classified into five distinct entities, each with different major pathophysiologic mechanisms. CRS type 1 most commonly occurs in the setting of acutely decompensated heart failure where approximately 25% of patients develop a rise in serum creatinine and a reduction of urine output after the first several doses of intravenous diuretics. Altered cardiac and renal hemodynamics are believed to be the most important determinants of CRS type 1. CRS type 2 is the hastened progression of chronic kidney disease (CKD) in the setting of chronic heart failure. Accelerated renal cell apoptosis and replacement fibrosis is considered to be the dominant mechanism. CRS type 3 is acutely decompensated heart failure after acute kidney injury from inflammatory, toxic, or ischemic insults. This syndrome is precipitated by salt and water overload, acute uremic myocyte dysfunction, and neurohormonal dysregulation. CRS type 4 is manifested by the acceleration of the progression of chronic heart failure in the setting of CKD. Cardiac myocyte dysfunction and fibrosis, so-called 'CKD cardiomyopathy', is believed to be the predominant pathophysiologic mechanism. Type 5 CRS is simultaneous acute cardiac and renal injury in the setting of an overwhelming systemic insult such as sepsis. In this scenario, the predominant pathophysiological disturbance is microcirculatory dysfunction as a result of acutely abnormal immune cell signaling, catecholamine cellular toxicity, and enzymatic activation which result in simultaneous organ injury often extending beyond both the heart and the kidneys. This paper will summarize these and other key findings from an international consensus conference on the spectrum of pathophysiologic mechanisms at work in the CRS.

Original languageEnglish (US)
Title of host publicationADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes
Pages82-98
Number of pages17
DOIs
StatePublished - Jun 24 2013

Publication series

NameContributions to Nephrology
Volume182
ISSN (Print)0302-5144

ASJC Scopus subject areas

  • Nephrology

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    McCullough, P. A., Kellum, J. A., Haase, M., Müller, C., Damman, K., Murray, P. T., Cruz, D., House, A. A., Schmidt-Ott, K. M., Vescovo, G., Bagshaw, S. M., Hoste, E. A., Briguori, C., Braam, B., Chawla, L. S., Costanzo, M. R., Tumlin, J. A., Herzog, C. A., Mehta, R. L., ... Ronco, C. (2013). Pathophysiology of the cardiorenal syndromes: Executive summary from the eleventh consensus conference of the acute dialysis quality initiative (ADQI). In ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes (pp. 82-98). (Contributions to Nephrology; Vol. 182). https://doi.org/10.1159/000349966