Pathophysiology of the aquaporin water channels

Research output: Contribution to journalArticle

Abstract

Discovery of aquaporin water channel proteins has provided insight into the molecular mechanism of membrane water permeability. The distribution of known mammalian aquaporins predicts roles in physiology and disease. Aquaporin-1 mediates proximal tubule fluid reabsorption, secretion of aqueous humor and cerebrospinal fluid, and lung water homeostasis. Aquaporin-2 mediates vasopressin-dependent renal collecting duct water permeability; mutations or downregulation can cause nephrogenic diabetes insipidus. Aquaporin-3 in the basolateral membrane of the collecting duct provides an exit pathway for reabsorbed water. Aquaporin-4 is abundant in brain and probably participates in reabsorption of cerebrospinal fluid, osmoregulation, and regulation of brain edema. Aquaporin-5 mediates fluid secretion in salivary and lacrimal glands and is abundant in alveolar epithelium of the lung. Specific regulation of membrane water permeability will likely prove important to understanding edema formation and fluid balance in both normal physiology and disease.

Original languageEnglish (US)
Pages (from-to)619-648
Number of pages30
JournalAnnual Review of Physiology
Volume58
StatePublished - 1996

Fingerprint

Aquaporins
Water
Fluids and Secretions
Permeability
Membranes
Cerebrospinal Fluid
Aquaporin 5
Aquaporin 3
Aquaporin 2
Nephrogenic Diabetes Insipidus
Aquaporin 1
Aquaporin 4
Osmoregulation
Lacrimal Apparatus
Lung
Water-Electrolyte Balance
Aqueous Humor
Brain Edema
Salivary Glands
Vasopressins

Keywords

  • brain
  • diabetes insipidus
  • edema
  • lung
  • water permeability

ASJC Scopus subject areas

  • Physiology

Cite this

Pathophysiology of the aquaporin water channels. / King, Landon Stuart; Agre, Peter C.

In: Annual Review of Physiology, Vol. 58, 1996, p. 619-648.

Research output: Contribution to journalArticle

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