Pathophysiology of keratoconus: What do we know today

Uri Soiberman; James W. Foster; Albert S. Jun; Shukti Chakravarti

doi:10.2174/1874364101711010252

Pathophysiology of keratoconus: What do we know today

Uri Soiberman, James W. Foster, Albert S. Jun, Shukti Chakravarti

School of Medicine

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Keratoconus is a common corneal ectasia that leads to progressive visual impairment. Numerous studies have shown abnormal protein expression patterns in keratoconic corneas. However, the specific mechanisms causing this disease remain ambiguous. This review aims to provide an update on morphological studies of the keratoconic cornea, relate these early studies with current findings from proteomic, biochemical and cell culture studies and to postulate possible pathogenic pathways.

Original language	English (US)
Pages (from-to)	252-261
Number of pages	10
Journal	Open Ophthalmology Journal
Volume	11
DOIs	https://doi.org/10.2174/1874364101711010252
State	Published - Jul 1 2017

Keywords

Corneal epithelium
Cytokine
Keratoconus
Keratocytes
Morphology
Oxidative stress
Pathogenesis
Proteomics
TGF-β

ASJC Scopus subject areas

Ophthalmology

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10.2174/1874364101711010252

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title = "Pathophysiology of keratoconus: What do we know today",

abstract = "Keratoconus is a common corneal ectasia that leads to progressive visual impairment. Numerous studies have shown abnormal protein expression patterns in keratoconic corneas. However, the specific mechanisms causing this disease remain ambiguous. This review aims to provide an update on morphological studies of the keratoconic cornea, relate these early studies with current findings from proteomic, biochemical and cell culture studies and to postulate possible pathogenic pathways.",

keywords = "Corneal epithelium, Cytokine, Keratoconus, Keratocytes, Morphology, Oxidative stress, Pathogenesis, Proteomics, TGF-β",

author = "Uri Soiberman and Foster, {James W.} and Jun, {Albert S.} and Shukti Chakravarti",

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year = "2017",

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doi = "10.2174/1874364101711010252",

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AU - Soiberman, Uri

AU - Foster, James W.

AU - Jun, Albert S.

AU - Chakravarti, Shukti

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Keratoconus is a common corneal ectasia that leads to progressive visual impairment. Numerous studies have shown abnormal protein expression patterns in keratoconic corneas. However, the specific mechanisms causing this disease remain ambiguous. This review aims to provide an update on morphological studies of the keratoconic cornea, relate these early studies with current findings from proteomic, biochemical and cell culture studies and to postulate possible pathogenic pathways.

AB - Keratoconus is a common corneal ectasia that leads to progressive visual impairment. Numerous studies have shown abnormal protein expression patterns in keratoconic corneas. However, the specific mechanisms causing this disease remain ambiguous. This review aims to provide an update on morphological studies of the keratoconic cornea, relate these early studies with current findings from proteomic, biochemical and cell culture studies and to postulate possible pathogenic pathways.

KW - Corneal epithelium

KW - Cytokine

KW - Keratoconus

KW - Keratocytes

KW - Morphology

KW - Oxidative stress

KW - Pathogenesis

KW - Proteomics

KW - TGF-β

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M3 - Review article

C2 - 28932341

AN - SCOPUS:85030773147

SN - 1874-3641

VL - 11

SP - 252

EP - 261

JO - Open Ophthalmology Journal

JF - Open Ophthalmology Journal

ER -

Pathophysiology of keratoconus: What do we know today

Abstract

Keywords

ASJC Scopus subject areas

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