Pathophysiology of exercise-induced asthma

Peyton A. Eggleston

Research output: Contribution to journalArticlepeer-review

Abstract

EGGLESTON, P. A. Pathophysiology of exercise-induced asthma. Med. Sci. Sports Exerc., Vol. 18, No. 3, pp. 318-321, 1986. The initiating stimulus for exercise-induced asthma in airway mucosal cooling or drying is caused by heat and water losses during exercise-related hyperventilation. It is not known how this stimulus is translated to bronchoconstriction, but the most convincing evidence is that mast cells are activated and release bronchospastic chemical mediators. The obstructive response appears to depend on the existence of abnormally reactive airways characteristically found in asthmatics. A number of modifying factors may be found during exercise, including plasma changes in cathecholamines and metabolite and acid-base status.

Original languageEnglish (US)
Pages (from-to)318-321
Number of pages4
JournalMedicine and Science in Sports and Exercise
Volume18
Issue number3
DOIs
StatePublished - Jun 1986

Keywords

  • Asthma
  • Exercise
  • Mast cells
  • Osmolality

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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