Pathophysiology of chronic urticaria

Lindsey A. Brodell; Lisa A. Beck; Sarbjit S. Saini

doi:10.1016/S1081-1206(10)60588-1

Pathophysiology of chronic urticaria

Lindsey A. Brodell, Lisa A. Beck, Sarbjit S. Saini

School of Medicine

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

Objective: To review the literature on the pathogenesis of chronic urticaria (excluding physical urticaria). Data Sources: PubMed was searched using the keywords urticaria and either chronic or autoimmune or pathogenesis for articles published from January 1972 to June 2007. All searches were limited to the English language. References from review articles on chronic urticaria were also considered for inclusion in this review. Study Selection: The authors selected relevant and current sources for inclusion in this review. Results: No concise pathogenic mechanism has been identified for all cases of chronic urticaria, although evidence for a serologic mediator that may be autoimmune in nature has been identified in many cases. The activation of basophils and/or mast cells is a central feature in any theory proposed to explain this troubling disease. Conclusion: Further research is needed to better define the mechanism or mechanism(s) responsible for the development of chronic urticaria. Such research will lead to more effective and possibly even curative treatments.

Original language	English (US)
Pages (from-to)	291-298
Number of pages	8
Journal	Annals of Allergy, Asthma and Immunology
Volume	100
Issue number	4
DOIs	https://doi.org/10.1016/S1081-1206(10)60588-1
State	Published - Apr 2008

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pulmonary and Respiratory Medicine

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title = "Pathophysiology of chronic urticaria",

abstract = "Objective: To review the literature on the pathogenesis of chronic urticaria (excluding physical urticaria). Data Sources: PubMed was searched using the keywords urticaria and either chronic or autoimmune or pathogenesis for articles published from January 1972 to June 2007. All searches were limited to the English language. References from review articles on chronic urticaria were also considered for inclusion in this review. Study Selection: The authors selected relevant and current sources for inclusion in this review. Results: No concise pathogenic mechanism has been identified for all cases of chronic urticaria, although evidence for a serologic mediator that may be autoimmune in nature has been identified in many cases. The activation of basophils and/or mast cells is a central feature in any theory proposed to explain this troubling disease. Conclusion: Further research is needed to better define the mechanism or mechanism(s) responsible for the development of chronic urticaria. Such research will lead to more effective and possibly even curative treatments.",

author = "Brodell, {Lindsey A.} and Beck, {Lisa A.} and Saini, {Sarbjit S.}",

note = "Funding Information: This feature is funded in part by an educational grant from AstraZeneca LP Funding Information: Funding Sources: University of Rochester School of Medicine and Dentistry Office of Medical Education (OME) Medical Student Research Funds Application (Ms Brodell); American Academy of Allergy, Asthma and Immunology Summer Research Fellowship Grant (Ms Brodell); and National Institute of Health grant AI070345 (Dr Saini). ",

year = "2008",

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doi = "10.1016/S1081-1206(10)60588-1",

language = "English (US)",

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AU - Brodell, Lindsey A.

AU - Beck, Lisa A.

AU - Saini, Sarbjit S.

N1 - Funding Information: This feature is funded in part by an educational grant from AstraZeneca LP Funding Information: Funding Sources: University of Rochester School of Medicine and Dentistry Office of Medical Education (OME) Medical Student Research Funds Application (Ms Brodell); American Academy of Allergy, Asthma and Immunology Summer Research Fellowship Grant (Ms Brodell); and National Institute of Health grant AI070345 (Dr Saini).

PY - 2008/4

Y1 - 2008/4

N2 - Objective: To review the literature on the pathogenesis of chronic urticaria (excluding physical urticaria). Data Sources: PubMed was searched using the keywords urticaria and either chronic or autoimmune or pathogenesis for articles published from January 1972 to June 2007. All searches were limited to the English language. References from review articles on chronic urticaria were also considered for inclusion in this review. Study Selection: The authors selected relevant and current sources for inclusion in this review. Results: No concise pathogenic mechanism has been identified for all cases of chronic urticaria, although evidence for a serologic mediator that may be autoimmune in nature has been identified in many cases. The activation of basophils and/or mast cells is a central feature in any theory proposed to explain this troubling disease. Conclusion: Further research is needed to better define the mechanism or mechanism(s) responsible for the development of chronic urticaria. Such research will lead to more effective and possibly even curative treatments.

AB - Objective: To review the literature on the pathogenesis of chronic urticaria (excluding physical urticaria). Data Sources: PubMed was searched using the keywords urticaria and either chronic or autoimmune or pathogenesis for articles published from January 1972 to June 2007. All searches were limited to the English language. References from review articles on chronic urticaria were also considered for inclusion in this review. Study Selection: The authors selected relevant and current sources for inclusion in this review. Results: No concise pathogenic mechanism has been identified for all cases of chronic urticaria, although evidence for a serologic mediator that may be autoimmune in nature has been identified in many cases. The activation of basophils and/or mast cells is a central feature in any theory proposed to explain this troubling disease. Conclusion: Further research is needed to better define the mechanism or mechanism(s) responsible for the development of chronic urticaria. Such research will lead to more effective and possibly even curative treatments.

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Pathophysiology of chronic urticaria

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