Abstract
The inherited marrow failure syndromes are a diverse set of genetic disorders characterized by hematopoietic aplasia and cancer predisposition. The clinical phenotypes are highly variable and much broader than previously recognized. The medical management of the inherited marrow failure syndromes differs from that of acquired aplastic anemia or malignancies arising in the general population. Diagnostic workup, molecular pathogenesis, and clinical treatment are reviewed.
Original language | English (US) |
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Pages (from-to) | 101-122 |
Number of pages | 22 |
Journal | Blood Reviews |
Volume | 24 |
Issue number | 3 |
DOIs | |
State | Published - May 2010 |
Externally published | Yes |
Keywords
- Aplastic anemia
- Diamond-Blackfan anemia
- Dyskeratosis congenita
- Fanconi
- Inherited bone marrow failure syndromes
- Shwachman-Diamond syndrome
ASJC Scopus subject areas
- Hematology
- Oncology