TY - JOUR
T1 - Pathophysiological mechanisms underlying ventricular dyssynchrony.
AU - Cheng, Alan
AU - Helm, Robert H.
AU - Abraham, Theodore P.
PY - 2009/11
Y1 - 2009/11
N2 - Left ventricular dyssynchrony due to conduction system disease creates cardiac inefficiency even in normal hearts. Dyssynchrony in the failing heart results in the development of a discrete heart failure phenotype as it induces chamber heterogeneity at the cellular and molecular levels that leads to impaired excitation-contraction coupling, increased arrhythmia susceptibility, and decreased myocyte survival among other pathologic changes. Recent research has demonstrated that these biomolecular changes are amazingly reversed with cardiac resynchronization therapy, providing insight into how to target the therapy.
AB - Left ventricular dyssynchrony due to conduction system disease creates cardiac inefficiency even in normal hearts. Dyssynchrony in the failing heart results in the development of a discrete heart failure phenotype as it induces chamber heterogeneity at the cellular and molecular levels that leads to impaired excitation-contraction coupling, increased arrhythmia susceptibility, and decreased myocyte survival among other pathologic changes. Recent research has demonstrated that these biomolecular changes are amazingly reversed with cardiac resynchronization therapy, providing insight into how to target the therapy.
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U2 - 10.1093/europace/eup272
DO - 10.1093/europace/eup272
M3 - Article
C2 - 19861385
AN - SCOPUS:75549087614
SN - 1099-5129
VL - 11 Suppl 5
SP - v10-14
JO - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
JF - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
ER -