TY - JOUR
T1 - Pathophysiological changes in calf muscle predict mobility loss at 2-year follow-up in men and women with peripheral arterial disease
AU - McDermott, Mary McGrae
AU - Ferrucci, Luigi
AU - Guralnik, Jack
AU - Tian, Lu
AU - Liu, Kiang
AU - Hoff, Frederick
AU - Liao, Yihua
AU - Criqui, Michael H.
PY - 2009/9
Y1 - 2009/9
N2 - BACKGROUND-: Associations of pathophysiological calf muscle characteristics with functional decline in people with lower extremity peripheral arterial disease are unknown. METHODS AND RESULTS-: Three hundred seventy participants with peripheral arterial disease underwent baseline measurement of calf muscle area, density, and percent fat with the use of computed tomography. Participants were followed up annually for 2 years. The outcome of mobility loss was defined as becoming unable to walk 1/4 mile or walk up and down 1 flight of stairs without assistance among those without baseline mobility limitations. Additional outcomes were 20% decline in 6-minute walk distance and becoming unable to walk for 6 minutes continuously among participants who walked continuously for 6 minutes at baseline. With adjustment for age, sex, race, body mass index, the ankle-brachial index, smoking, physical activity, relevant medications, and comorbidities, lower calf muscle density (P for trend
AB - BACKGROUND-: Associations of pathophysiological calf muscle characteristics with functional decline in people with lower extremity peripheral arterial disease are unknown. METHODS AND RESULTS-: Three hundred seventy participants with peripheral arterial disease underwent baseline measurement of calf muscle area, density, and percent fat with the use of computed tomography. Participants were followed up annually for 2 years. The outcome of mobility loss was defined as becoming unable to walk 1/4 mile or walk up and down 1 flight of stairs without assistance among those without baseline mobility limitations. Additional outcomes were 20% decline in 6-minute walk distance and becoming unable to walk for 6 minutes continuously among participants who walked continuously for 6 minutes at baseline. With adjustment for age, sex, race, body mass index, the ankle-brachial index, smoking, physical activity, relevant medications, and comorbidities, lower calf muscle density (P for trend
KW - Aging
KW - Claudication
KW - Muscles
KW - Peripheral vascular disease
KW - Prognosis
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U2 - 10.1161/CIRCULATIONAHA.108.842328
DO - 10.1161/CIRCULATIONAHA.108.842328
M3 - Article
C2 - 19738138
AN - SCOPUS:70349656513
SN - 0009-7322
VL - 120
SP - 1048
EP - 1055
JO - Circulation
JF - Circulation
IS - 12
ER -