Pathophysiologic role of selectins and their ligands in ischemia reperfusion injury.

F. Chamoun; M. Burne; M. O'Donnell; H. Rabb

doi:10.2741/chamoun

Pathophysiologic role of selectins and their ligands in ischemia reperfusion injury.

F. Chamoun, M. Burne, M. O'Donnell, H. Rabb

Research output: Contribution to journal › Review article › peer-review

85 Scopus citations

Abstract

Research findings are unveiling the potential role of leukocytes and leukocyte adhesion molecules such as selectins in ischemia-reperfusion injury (IRI). "Anti-adhesion" therapy using selectin blocking agents may represent a new approach to treatment of the many diverse clinical disorders in which ischemia-reperfusion occurs, including transplantation, reperfusion after thrombotic events and shock. In this paper we review the pathophysiology of IRI, the different types of selectins and selectin ligands, the clinical implications of selectin blockade in different organs with IRI, and new insights into mechanism of action.

Original language	English (US)
Pages (from-to)	E103-109
Journal	Frontiers in bioscience : a journal and virtual library
Volume	5
DOIs	https://doi.org/10.2741/chamoun
State	Published - Nov 1 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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AU - Burne, M.

AU - O'Donnell, M.

AU - Rabb, H.

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Y1 - 2000/11/1

N2 - Research findings are unveiling the potential role of leukocytes and leukocyte adhesion molecules such as selectins in ischemia-reperfusion injury (IRI). "Anti-adhesion" therapy using selectin blocking agents may represent a new approach to treatment of the many diverse clinical disorders in which ischemia-reperfusion occurs, including transplantation, reperfusion after thrombotic events and shock. In this paper we review the pathophysiology of IRI, the different types of selectins and selectin ligands, the clinical implications of selectin blockade in different organs with IRI, and new insights into mechanism of action.

AB - Research findings are unveiling the potential role of leukocytes and leukocyte adhesion molecules such as selectins in ischemia-reperfusion injury (IRI). "Anti-adhesion" therapy using selectin blocking agents may represent a new approach to treatment of the many diverse clinical disorders in which ischemia-reperfusion occurs, including transplantation, reperfusion after thrombotic events and shock. In this paper we review the pathophysiology of IRI, the different types of selectins and selectin ligands, the clinical implications of selectin blockade in different organs with IRI, and new insights into mechanism of action.

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Pathophysiologic role of selectins and their ligands in ischemia reperfusion injury.

Abstract

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