Pathology of iris in leprosy

Ebenezer Daniel, Gigi Ebenezer, Charles K. Job

Research output: Contribution to journalArticle

Abstract

Aim - The histopathological features of the iris in leprosy were studied by light microscopy. Method - Formalin fixed and paraffin embedded iris tissue excised during cataract surgery from 20 leprosy patients were sectioned and studied with haematoxylin and eosin stain and modified Fite Faraco's stain for acid fast bacilli (AFB). Results - Chronic inflammatory reactions were seen in the iris of 11 patients, seven of whom did not have any clinically demonstrable evidence of iridocyclitis. Smooth muscle disruption and destruction were seen in two specimens. AFB were found in the iris tissue of a polar lepromatous patient whose skin smears were negative for AFB and who had completed the WHO recommended antileprosy multidrug therapy (MDT). Conclusion - Histopathology discloses far more silent chronic iridocyclitis in leprosy patients than are diagnosed clinically. AFB can persist in the iris tissue even after completion of MDT. Smooth muscle disruption and destruction, a cause of the miotic pupil in leprosy has been conclusively demonstrated histopathologically.

Original languageEnglish (US)
Pages (from-to)490-492
Number of pages3
JournalBritish Journal of Ophthalmology
Volume81
Issue number6
StatePublished - Jun 1997
Externally publishedYes

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Iris
Leprosy
Bacillus
Pathology
Iridocyclitis
Acids
Smooth Muscle
Coloring Agents
Miotics
Hematoxylin
Eosine Yellowish-(YS)
Pupil
Paraffin
Cataract
Formaldehyde
Microscopy
Light
Skin
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Daniel, E., Ebenezer, G., & Job, C. K. (1997). Pathology of iris in leprosy. British Journal of Ophthalmology, 81(6), 490-492.

Pathology of iris in leprosy. / Daniel, Ebenezer; Ebenezer, Gigi; Job, Charles K.

In: British Journal of Ophthalmology, Vol. 81, No. 6, 06.1997, p. 490-492.

Research output: Contribution to journalArticle

Daniel, E, Ebenezer, G & Job, CK 1997, 'Pathology of iris in leprosy', British Journal of Ophthalmology, vol. 81, no. 6, pp. 490-492.
Daniel, Ebenezer ; Ebenezer, Gigi ; Job, Charles K. / Pathology of iris in leprosy. In: British Journal of Ophthalmology. 1997 ; Vol. 81, No. 6. pp. 490-492.
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