TY - JOUR
T1 - Pathology of genetically engineered mouse models of pancreatic exocrine cancer
T2 - Consensus report and recommendations
AU - Hruban, Ralph H.
AU - Adsay, N. Volkan
AU - Albores-Saavedra, Jorge
AU - Anver, Miriam R.
AU - Biankin, Andrew V.
AU - Boivin, Gregory P.
AU - Furth, Emma E.
AU - Furukawa, Toru
AU - Klein, Alison
AU - Klimstra, David S.
AU - Kloppel, Gunter
AU - Lauwers, Gregory Y.
AU - Longnecker, Daniel S.
AU - Luttges, Jutta
AU - Maitra, Anirban
AU - Offerhaus, G. Johan A.
AU - Pérez-Gallego, Lucía
AU - Redston, Mark
AU - Tuveson, David A.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Several diverse genetically engineered mouse models of pancreatic exocrine neoplasia have been developed. These mouse models have a spectrum of pathologic changes; however, until now, there has been no uniform nomenclature to characterize these changes. An international workshop, sponsored by The National Cancer Institute and the University of Pennsylvania, was held from December 1 to 3, 2004 with the goal of establishing an internationally accepted uniform nomenclature for the pathology of genetically engineered mouse models of pancreatic exocrine neoplasia. The pancreatic pathology in 12 existing mouse models of pancreatic neoplasia was reviewed at this workshop, and a standardized nomenclature with definitions and associated images was developed. It is our intention that this nomenclature will standardize the reporting of genetically engineered mouse models of pancreatic exocrine neoplasia, that it will facilitate comparisons between genetically engineered mouse models and human pancreatic disease, and that it will be broad enough to accommodate newly emerging mouse models of pancreatic neoplasia.
AB - Several diverse genetically engineered mouse models of pancreatic exocrine neoplasia have been developed. These mouse models have a spectrum of pathologic changes; however, until now, there has been no uniform nomenclature to characterize these changes. An international workshop, sponsored by The National Cancer Institute and the University of Pennsylvania, was held from December 1 to 3, 2004 with the goal of establishing an internationally accepted uniform nomenclature for the pathology of genetically engineered mouse models of pancreatic exocrine neoplasia. The pancreatic pathology in 12 existing mouse models of pancreatic neoplasia was reviewed at this workshop, and a standardized nomenclature with definitions and associated images was developed. It is our intention that this nomenclature will standardize the reporting of genetically engineered mouse models of pancreatic exocrine neoplasia, that it will facilitate comparisons between genetically engineered mouse models and human pancreatic disease, and that it will be broad enough to accommodate newly emerging mouse models of pancreatic neoplasia.
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U2 - 10.1158/0008-5472.CAN-05-2168
DO - 10.1158/0008-5472.CAN-05-2168
M3 - Article
C2 - 16397221
AN - SCOPUS:31544467540
SN - 0008-5472
VL - 66
SP - 95
EP - 106
JO - Cancer Research
JF - Cancer Research
IS - 1
ER -